Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate.

International Journal of Biological Macromolecules
Zhang YuqingHu Yuanliang

Abstract

In order to screen better flavone prescriptions of anti-Newcastle disease virus (NDV), four flavone ingredients of epimedium flavones (EF), baikal skullcap root flavones (BSRF), wild dendranthema flower flavones (WDFF), and sanchi flavones (SF) screened in previous experiments and their prescriptions were added into chicken embryo fibroblast monolayer with three drug-adding modes respectively. The cellular A(570) values, the highest virus inhibitory rates and the score based on virus inhibitory rate were calculated to compare their antiviral activity. In immune protective test, the effects of three preparations (EF-BSRF, EF-SF-WDFF-BSRF and EF-WDFF-BSRF screened by the results in vitro experiment) on NDV infection were compared in chickens vaccinated with ND vaccine then challenged with NDV. Blood was regularly sampled for serum antibody titer determination. The pathogenic and dead statuses of chickens were clinically examined. The results indicated that the A(570) values of the nine prescriptions, especially the foresaid three prescriptions at almost all concentrations in three drug-adding modes were significantly higher than that of the virus control group. The foresaid three prescriptions presented at the top five of the hig...Continue Reading

References

Aug 26, 1999·Trends in Biotechnology·M Vidal, H Endoh
Sep 2, 2004·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jie Zhang, Lie-Ming Xu
Mar 3, 2005·Journal of Agricultural and Food Chemistry·Katheline HuaDominique P Bureau
Dec 7, 2007·International Journal of Biological Macromolecules·Xiaoyan HuangJunling Sun
Aug 12, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·P SchnitzlerJürgen Reichling
Apr 21, 2009·Virus Research·Sang-Moo KangRichard W Compans
Mar 8, 2012·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Jingli Wang, Chaofan Zhou

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Citations

Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xia MaYunpeng Fan
Feb 24, 2016·The Journal of Veterinary Medical Science·Yan JiaLiwen Hu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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