Flavonoid alkaloids from Scutellaria moniliorrhiza with anti-inflammatory activities and inhibitory activities against aldose reductase

Phytochemistry
Qing-Tong HanSheng-Jun Dai

Abstract

Four undescribed flavonoid alkaloids, as two pairs of enantiomers, were initially isolated as a racemate from the whole plant of Scutellaria moniliorrhiza. By means of chiral HPLC, four isomers, named scumonilines A-D, were successfully separated, and their chemical structures including absolute configurations were established by mass as well as NMR spectroscopy and CD technique. In vitro, four flavonoid alkaloids showed anti-inflammatory activities, with IC50 values against the release of β-glucuronidase from polymorphonuclear leukocytes of rats being in the range 5.16-5.85 μΜ. Moreover, four compounds were evaluated for their inhibitory activities against aldose reductase, and gave IC50 values in the range 2.29-3.03 μΜ.

Citations

Dec 14, 2019·European Journal of Medicinal Chemistry·Paul AwoladeParvesh Singh
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahMariusz Jaremko
Apr 25, 2021·Natural Products and Bioprospecting·Jian-Jun ZhaoGang Xu

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