Flavonoid and phenolic acid profile by LC-MS/MS and biological activity of crude extracts from Chenopodium hybridum aerial parts

Natural Product Research
I PodolakR Nowak

Abstract

Extracts from leaves and stems of Chenopodium hybridum were characterised for the presence and quantity of flavonoids and phenolic acids by LC-ESI-MS/MS. Five flavonoids and eight phenolic acids were detected for the first time in aerial parts of this plant species, the most abundant compounds being rutin (2.80 μg/g DW), 3-kaempferol rutinoside (2.91 μg/g DW), 4-OH-benzoic (1.86 μg/g DW) and syringic acids (2.31 μg/g DW). Extracts were tested for anti-inflammatory/antiarthritic, antihyaluronidase and cytotoxic activities against human prostate cancer (Du145, PC3) and melanoma cell lines (A375, HTB140 and WM793) of different malignancy. None of the extracts protected bovine serum albumin from heat-induced denaturation. Antihyaluronidase effect at the tested concentration was higher than standard naringenin. Cytotoxic activity was generally low with an exception of the extract from the leaves, which was found most effective against prostate Du145 cell line with 98.28 ± 1.13% of dead cells at 100 μg/mL.

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Citations

Sep 2, 2016·Chemical & Pharmaceutical Bulletin·Rémy Bertrand TeponnoTomofumi Miyamoto
Apr 13, 2017·Natural Product Research·Shu-Qun HouYu-Kui Li
Jun 9, 2018·Natural Product Research·Zlatina Kokanova-NedialkovaGeorgi Momekov
Mar 16, 2017·Natural Product Research·Hameed Shah, Ashfaq Ahmad Khan
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karolina GrabowskaIrma Podolak

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