Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Chang-Suk KongYoungwan Seo

Abstract

Flavonoid glycosides, isorhamnetin 3-capital O, Cyrillic-beta-d-glucoside, and quercetin 3-O-beta-d-glucoside were isolated from Salicornia herbacea and their inhibitory effects on matrix metalloproteinase-9 and -2 (MMP-9 and -2) were evaluated in human fibrosarcoma cell line (HT1080). In zymography experiments, these flavonoid glycosides led to the reduction of the expression levels and activities of MMP-9 and -2 without any significant difference between these flavonoid glycosides. Protein expression levels of both MMP-9 and MMP-2 were inhibited and TIMP-1 (tissue inhibitor of metalloproteinase-1) protein level was enhanced by these flavonoid glycosides. Moreover, a transfection study carried out with AP-1 reporter construct revealed that the reporter activity was suppressed by treatment with isorhamnetin 3-capital O, Cyrillic-beta-d-glucoside. Therefore, these results suggested that these flavonoid glycosides have a potential as valuable natural chemopreventive agents for cancer.

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Citations

May 19, 2010·Marine Drugs·Ramjee PallelaSe-Kwon Kim
Jan 5, 2011·Biochemistry Research International·Noel Vinay Thomas, Se-Kwon Kim
Sep 18, 2012·Immunopharmacology and Immunotoxicology·Chang-Suk Kong, Youngwan Seo
Oct 14, 2014·Marine Drugs·Fatih KaradenizChang-Suk Kong
Jun 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyong-Hwa KangSe-Kwon Kim
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Apr 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kateřina ValentováVladimír Křen
Mar 18, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sun-Chae KimSung-Hoon Kim
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