Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood

European Journal of Nutrition
Katharina J PenczynskiAnette E Buyken

Abstract

Flavonoid consumption during adolescence could contribute to preventing adult onset of type 2 diabetes mellitus. We investigated the prospective association between habitual intake of flavonoids from fruit and vegetables (FlavFV) during adolescence and risk markers of type 2 diabetes in early adulthood. This analysis included participants of the DONALD Study, who had provided a fasting blood sample in adulthood (18-39 years), data on FlavFV-intake during adolescence (females: 9-15 years, males: 10-16 years) and relevant covariates. Habitual FlavFV-intake was either estimated using repeated 3-day weighed dietary records (n = 268), or the validated biomarker hippuric acid (uHA)-excretion in repeated 24-h urine samples (n = 241). Multivariable linear regressions were performed to analyse the prospective associations of FlavFV or uHA with homeostasis model assessment insulin sensitivity (HOMA2-%S), hepatic steatosis index (HSI), fatty liver index (FLI) and a pro-inflammatory score. Higher FlavFV-intake was independently related to higher HOMA2-%S among females (Ptrend = 0.03), but not among males. Both FlavFV-intake and uHA-excretion were inversely associated with HSI (Ptrend < 0.0001 and Ptrend = 0.02, respectively) and the pro-in...Continue Reading

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Citations

Aug 4, 2020·American Journal of Physiology. Renal Physiology·Yifan HuaThomas Remer
Mar 25, 2019·European Journal of Nutrition·Ratih Wirapuspita WisnuwardaniNathalie Michels
Aug 1, 2018·European Journal of Nutrition·Ratih Wirapuspita WisnuwardaniNathalie Michels
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May 24, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Juliana NyasordziAnette E Buyken
Jun 8, 2021·Frontiers in Endocrinology·Qing FangDongsheng Ouyang
Jul 15, 2021·The American Journal of Clinical Nutrition·Dohyun ByunHannah Oh

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