PMID: 10851537Jun 1, 1996Paper

Flavonoid-mediated tumor growth suppression demonstrated by in vivo study

Cancer Biotherapy & Radiopharmaceuticals
H KameiY Hashimoto

Abstract

Many of flavonoids as well as bioflavonoids extracted from higher plants, which were earlier revealed to have tumor cell growth suppression activity in vitro, were examined for their effect on tumors in vivo. Balb/c mice were inoculated i.p. with syngeneic tumor cells, meth/a, and then provided with flavonoids dissolved in their drinking water during the course of their survival time. Many flavonoids were effective in prolonging the survival period. Furthermore, flavonoids that did not show suppressive activities in the in vitro experiments were effective in the in vivo assay. The data suggested that sugar bonded to the A ring, which suppresses tumor growth inhibition in vitro, plays an important role. Many aglycones that were effective in the in vitro assay on the tumor growth suppression were not effective in the in vivo assay. The reason for this seems to be that most aglycones are unstable and thus break down in vivo. No acute nor chronic toxicity of flavonoids was observed in the mice.

References

Nov 1, 1991·Journal of Natural Products·M Cushman, D Nagarathnam
Jan 1, 1995·Cancer Investigation·H KameiK Terabe
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G G ChabotS Chouaib

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Citations

Aug 1, 1996·Cancer Biotherapy & Radiopharmaceuticals·T KoideM Hasegawa
Feb 1, 1997·Cancer Biotherapy & Radiopharmaceuticals·H KameiM Hasegawa
Jun 14, 2000·Cancer Biotherapy & Radiopharmaceuticals·H KameiM Hasegawa
Jun 19, 2009·Current Opinion in Oncology·Oluyemisi AkinwandeClement Adebamowo
Nov 19, 2011·Pharmacognosy Reviews·Maheep K ChaharYogesh C Joshi
Mar 17, 2010·Plant Physiology and Biochemistry : PPB·Alessandro LentiniSimone Beninati
Oct 16, 2015·BMC Complementary and Alternative Medicine·Izabel Cristina Gomes de MendonçaFrancisco Stefânio Barreto
Apr 24, 2003·Medicinal Research Reviews·Wenying RenLi Zhang
Nov 1, 2018·Brazilian Journal of Biology = Revista Brasleira De Biologia·F R G SilvaA F Santos
Aug 1, 1997·Cancer Biotherapy & Radiopharmaceuticals·T KoideK Terabe
Apr 3, 2018·Journal of Agricultural and Food Chemistry·Wenzhao WangTao Xia

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