Flavonoids, apigenin and icariin exert potent melanogenic activities in murine B16 melanoma cells

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Yan YeZhi-Ling Yu

Abstract

We aimed to screen for melanogenic agents among 35 botanical compounds. The compounds were first assessed with regard to their effects on tyrosinase activity in B16 cells. At 100 μM, 13 compounds showed tyrosinase activity-enhancing effects, ranging from 2.6 to 372.8% activation. Five of them showed more than 50% enhancement and were further tested for their EC(50) values. Compared with 8-Methoxypsoralen, an effective tyrosinase activator with an EC(50) of 7.26 μM, 3 compounds exhibited smaller EC(50) values (apigenin, 0.45 μM; hyperosid, 0.92 μM; and icariin, 1.01 μM for enhancing tyrosinase activity). The 3 compounds significantly increased cellular melanin contents without affecting cell proliferation. Compared with 8-Methoxypsoralen (EC(50), 35.94 μM for stimulating pigmentation), apigenin (EC(50), 17.46 μM) and icariin (EC(50), 32.77 μM) showed better melanogenic activity, while hyperosid (EC(50), 70.4 μM) was less potent. Western blot analysis demonstrated that the 3 compounds could differentially increase the expression levels of tyrosinase, and tyrosinase-related proteins 1 and 2. Together these data suggest that apigenin and icariin exert potent melanogenic activities through, at least in part, upregulating the protein...Continue Reading

References

Oct 28, 1999·The Journal of Investigative Dermatology. Symposium Proceedings·V J Hearing
Nov 9, 2005·Peptides·Paula C EvesJohn W Haycock
Dec 5, 2006·International Journal of Oncology·Deendayal PatelSanjay Gupta
Jan 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gertrude-E Costin, Vincent J Hearing
Nov 26, 2009·The Medical Clinics of North America·Paul T Rose

❮ Previous
Next ❯

Citations

Jan 18, 2014·Bioorganic & Medicinal Chemistry·Kosei YamauchiIrmanida Batubara
Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kosei YamauchiTohru Suzuki
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nadia MustaphaLeila Chekir-Ghedira
May 27, 2016·Pharmaceutical Biology·Li ZhuYan-Hua Lu
Feb 13, 2016·Molecular Nutrition & Food Research·Feng Liu-Smith, Frank L Meyskens
Nov 11, 2016·BMC Complementary and Alternative Medicine·Amalia Di PetrilloAntonella Fais
Sep 7, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrei MocanAdriano Mollica
Feb 15, 2018·Journal of Natural Medicines·Kosei Yamauchi, Tohru Mitsunaga
Aug 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao Niu, Haji A Aisa
Jan 3, 2020·Natural Product Research·Luis Apaza TiconaÁngel Rumbero Sánchez
Sep 19, 2018·BMC Complementary and Alternative Medicine·Sa-Haeng KangYoung-Mi Lee
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thouria BourhimChemseddoha Gadhi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.