Flavonoids as protective agents against oxidative stress induced by gentamicin in systemic circulation. Potent protective activity and microbial synergism of luteolin

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Pamela Soledad BustosMaría Gabriela Ortega

Abstract

The flavonoids effect on gentamicin (GEN)-induced oxidative stress (OS) in systemic circulation was evaluated in terms of reactive oxygen species (ROS) production, enzymatic antioxidant defenses superoxide dismutase (SOD) and catalase (CAT), and lipid peroxidation (LP) in vitro on human leukocytes and in vivo on rat whole blood. The inhibitory activity of ROS was ATS < QTS < isovitexin < vitexin < luteolin. Luteolin, the most active, showed more inhibition in ROS production than vitamin C (reference inhibitor) in mononuclear cells and a slightly lower protective behavior compared to this inhibitor in polymorphonuclear cells. In both cellular systems, luteolin tends to level SOD and CAT activities modified by GEN, reaching basal values and preventing LP. In Wistar rats, GEN plus luteolin can suppress ROS generation, collaborate with SOD and CAT and diminish LP produced by GEN at therapeutic doses. Finally, luteolin and antibiotic association was evaluated on the antimicrobial activity in S. aureus and E. coli showing a synergism between GEN and luteolin on S. aureus ATCC and an additive effect on E. coli ATCC. Therefore, simultaneous administration of luteolin and GEN could represent a potential therapeutic option capable of pro...Continue Reading

Citations

Jan 29, 2020·Phytotherapy Research : PTR·Luiz Guilherme Salvino da SilvaRosângela Maria Neves Bezerra
Jan 8, 2020·Journal of Clinical Medicine·Artur AdamczakTomasz M Karpiński
Aug 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Duda-MadejEwa Dworniczek
May 4, 2021·TheScientificWorldJournal·Ibrahim Luru AbdulaiMichael Buenor Adinortey

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