Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Gopalsamy Rajiv GandhiRicardo Queiroz Gurgel

Abstract

Flavonoids are naturally occurring compounds, extensively distributed in plants. T helper (Th)1 and Th2 cytokines balance plays an essential role in the reaction of inflammatory, allergic and infectious processes and transplantation rejection. This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions. Articles in English published from inception to December 2017 reporting flavonoids with immunomodulatory activity for the management of immune-mediated disorders were acquired from PubMed, EMBASE, Scopus and Web of Science and a animal experiments where Th1 and Th2 cytokines were investigated to assess the outcome of immunoregulatory therapy were included. 1809 publications were identified and 26 were included in this review. Ten articles described the effect of flavonoids on allergic inflammation in an animal model of asthma; eleven in vivo studies evaluated the immunomodulating and immunosuppressive effects of flavonoids on Th1/Th2 cytokines production and five reports described the regulatory role of flavonoids for Th1/Th2 cytokine responses to experimental arthritis and myocarditis. Modulatio...Continue Reading

Citations

May 24, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yan YanJianfeng Xing
Mar 19, 2020·Journal of Food Biochemistry·Chengqiang WangJia-Le Song
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Oct 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michele CatanzaroCristina Lanni
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Feb 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinghui SongKaijiang Tang
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Jul 1, 2021·Journal of Ethnopharmacology·Lindiwe SibekoLorraine S Cordeiro
Jul 3, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ke ZhouHaiyang Xie
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