Flavonoids from the aerial parts of Houttuynia cordata attenuate lung inflammation in mice

Archives of Pharmacal Research
Ju Hee LeeHyun Pyo Kim

Abstract

The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in vitro and in vivo models of lung inflammation. The 70 % ethanol extract of the aerial parts of H. cordata inhibited the production of inflammatory biomarkers IL-6 and NO in lung epithelial cells (A549) and alveolar macrophages (MH-S), respectively. And the same plant material, administered orally (100 and 400 mg/kg), significantly inhibited lung inflammatory response in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. From the extract, major flavonoids including afzelin, hyperoside and quercitrin were successfully isolated and they also attenuated LPS-induced lung inflammation in mice by oral administration. In particular, quercitrin showed most potent activity at 100 mg/kg. These results demonstrate for the first time that H. cordata and three flavonoid constituents have a therapeutic potential for treating lung inflammatory disorders.

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Citations

Jul 6, 2016·Journal of Ethnopharmacology·Lara F AzevedoTati Ishikawa
Dec 14, 2016·Biomolecules & Therapeutics·Hyun Pyo KimYong Soo Kwon
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yasuko SekitaYoshiki Kashiwada
Apr 18, 2017·Experimental and Therapeutic Medicine·Xianyuan HuangJinmin Zhao
Jan 21, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li-Jun LingDao-Feng Chen

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