Flavonoids from Trollius europaeus flowers and evaluation of their biological activity

The Journal of Pharmacy and Pharmacology
Ewa Witkowska-Banaszczak

Abstract

This article describes the flavonoid composition of the flowers of Trollius europaeus and the method of isolation thereof and provides an attempt at investigating the antioxidant activity of the isolated flavonoids and the antityrosinase activity of the extracts from the investigated material. The compositional data were acquired by combining results of nuclear magnetic resonance, ultraviolet spectroscopy, electrospray ionisation-tandem mass spectrometry (ESI-MS/MS) analyses and those of an analysis of the products of acid hydrolysis of the compounds. The antioxidant activity of the extracts was studied using the 2,2'-diphenyl-1-picrylhydrazyl assay and the tyrosinase inhibitory activity - with the use of mushroom tyrosinase. Ten flavonoid derivatives of luteolin and apigenin were isolated from the flowers of T. europaeus and identified. The investigation into the antioxidant activity revealed that orientin 2″-O-α-arabinopyranoside (4) and orientin 2″-O-β glucopyranoside (5) had a significant antioxidant effect. The studies conducted led to the development of a method of isolating flavonoid, potentially antioxidant, compounds from T. europaeus. They allowed to determine which of the investigated flavonoids demonstrated signific...Continue Reading

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Citations

Apr 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan ZengHongliang Yao
Aug 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola PomaMonica Notarbartolo
Nov 20, 2018·Bulletin of Experimental Biology and Medicine·N E Sharanova, A V Vasil'ev

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