Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury

Journal of Ethnopharmacology
Rute F VitorAlexandra Paulo

Abstract

Pterospartum tridentatum is a Leguminosae that grows spontaneously in Portugal. The flowers are used in popular medicine for the treatment of throat irritation conditions and in herbal mixtures for diabetes. Diabetic vascular complications are due, among other reasons, to increased oxidative stress and for that reason antioxidants are believed to be beneficial for the diabetic patient. The flower water extract of this herbal drug showed dose-dependent protective effect of cultured human endothelial cells against oxidative injury induced by H2O2, at concentrations > or =0.3 mg/ml. This water extract, after liquid-liquid and chromatographic fractionation afforded one new isoflavone (5,5'-dihydroxy-3'-metoxi-isoflavone-7-O-beta-glucoside) and three other known isoflavones (prunetin, genistin and sissotrin). The structural characterisation of isolated compounds was achieved by UV, NMR and MS analysis. The flavonol glycoside isoquercitrin was also identified in the extract by HPLC analysis. Isoquercitrin is one of the active antioxidant principles of the extract since it showed dose-dependent protective effect against oxidative injury at concentrations > or =0.3 mM. Isoflavones were inactive at the same concentrations. The results s...Continue Reading

References

Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·H WeiY Wang
Feb 3, 2000·Phytochemistry·A C TalukdarH G Krishnamurty
Aug 5, 2000·Journal of Natural Products·P G Pietta
Dec 1, 2001·Endocrinology and Metabolism Clinics of North America·A A Taylor
May 4, 2002·Planta medica·Chun-Mao LinJen-Kun Lin

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Citations

Aug 16, 2008·Archives of Pharmacal Research·Jeong Mi Kim, Hye Sook Yun-Choi
Mar 29, 2007·Natural Product Reports·Nigel C Veitch
Mar 11, 2011·Natural Product Research·Mai FujiwaraMitsuo Miyazawa
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Ki Yong LeeYoung Choong Kim
May 12, 2007·The Review of Diabetic Studies : RDS·Charles Sia
Jul 31, 2013·International Journal of Molecular Sciences·Wan-Chun LaiFang-Rong Chang
Nov 28, 2015·Journal of Food Science·Bojana BalančBranko Bugarski
Dec 23, 2008·Journal of Ethnopharmacology·Amélia P RauterHélder Mota-Filipe
Sep 26, 2007·Phytochemistry·José M Narváez-MastacheGuillermo Delgado
Jun 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Takako YokozawaGen-Ichiro Nonaka
Jan 6, 2006·The Journal of Pharmacy and Pharmacology·Alexandra Paulo, Helder Mota-Filipe
Mar 24, 2010·Phytotherapy Research : PTR·Amélia P RauterJorge Justino
Oct 15, 2009·Phytotherapy Research : PTR·Teresa DiasAlexandra Paulo
Dec 28, 2010·Journal of Ethnopharmacology·Arquimedes Gasparotto JuniorCândida Aparecida Leite Kassuya
Mar 22, 2012·Journal of Dietary Supplements·Haseena Banu Hedayathullah KhanSachdanandam Panchanadham
Aug 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José PinelaIsabel C F R Ferreira
Jun 24, 2005·Pharmacology, Biochemistry, and Behavior·Jair Guilherme dos SantosLuzia Kalyne de Almeida Leal
Jun 4, 2020·Medicines·Diana C G A PintoArtur M S Silva
Feb 20, 2009·Menopause : the Journal of the North American Menopause Society·Michele PauloMaria Regina Torqueti Toloi
Sep 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bumjung KimKyungjin Lee
Feb 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mark A M SimõesArtur M S Silva
Apr 8, 2020·Archives of Pharmacal Research·Anowarul IslamMd Rashedunnabi Akanda
Nov 21, 2019·European Journal of Pharmacology·Taseer AhmadRichard Roberts
Apr 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mahendra P KapoorDaichi Nakamura
Jun 22, 2021·Journal of Biomolecular Structure & Dynamics·Shalini MathpalSubhash Chandra

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