Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate

Free Radical Biology & Medicine
So Ra KimYoung Choong Kim

Abstract

We previously reported 12 antioxidative flavonoids isolated from the n-BuOH extract of Inula britannica (Asteraceae). This prompted us to investigate further whether these flavonoids also showed antioxidative activity upon live cells grown in a culture system. Among the 12 flavonoids tested, only patuletin, nepetin, and axillarin protected primary cultures of rat cortical cells from oxidative stress induced by glutamate. These flavonoids exerted significant neuroprotective activity when they were administered either before or after the glutamate insult. Treatment with these flavonoids maintained the activities of such antioxidant enzymes as catalase, glutathione-peroxidase, and glutathione reductase, all of which play important roles in the antioxidative defense mechanism. Moreover, these three flavonoids also attenuated significant drops in glutathione induced by glutamate which is a routine concomitant of oxidative stress by inhibiting glutathione diminution. Accordingly, these flavonoids did not stimulate the synthesis of glutathione. With regard to structure-activity relationships, our results indicated that the 6-methoxyl group in the A ring and the 3', 4'-hydroxyl groups in the B ring are crucial for the protection agains...Continue Reading

References

Sep 1, 1985·Environmental Health Perspectives·J C Dearden
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Nov 1, 1993·Trends in Neurosciences·C W Olanow
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Jun 13, 1997·Brain Research·J W McDonaldD W Choi
Jun 25, 1998·The Journal of Cell Biology·S TanD Schubert
Jul 13, 1999·Free Radical Biology & Medicine·O TiroshL Packer
Jul 23, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·K HaïdaraF Denizeau
Jan 29, 2000·Journal of Natural Products·E J ParkJ Kim
Feb 22, 2001·Free Radical Biology & Medicine·K IshigeY Sagara
Feb 24, 2001·The Journal of Pharmacy and Pharmacology·S R KimY C Kim
May 29, 2001·Current Medicinal Chemistry·L M SayreG Perry
Aug 1, 1997·Cell Death and Differentiation·P Nicotera, M Leist

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Citations

Dec 19, 2013·Archives of Pharmacal Research·Soo-Jin ChooIck-Dong Yoo
Aug 12, 2009·Journal of Ethnopharmacology·Weijian BeiChuyuan Li
May 26, 2009·Biomedical and Environmental Sciences : BES·De-Hong YuMing Yang
May 2, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H S CuiK Bae
Apr 17, 2010·Molecular Nutrition & Food Research·Kyung-Sook ChungKyung-Tae Lee
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdul Latif KhanIn-Jung Lee
Sep 14, 2007·Platelets·Beata Olas, Barbara Wachowicz
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Sik KimHocheol Kim
Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Zui Chen, Long Qiu Cheng
Jan 26, 2010·Journal of Agricultural and Food Chemistry·Carolina EcheverryFederico Dajas
Nov 6, 2007·Bioorganic & Medicinal Chemistry·Tatiana HerreriasMaria E M Rocha
Sep 24, 2021·Journal of Biomolecular Structure & Dynamics·Musherah M AlshammariAshanul Haque

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