Flavonoids of Polygonum hydropiper L. attenuates lipopolysaccharide-induced inflammatory injury via suppressing phosphorylation in MAPKs pathways

BMC Complementary and Alternative Medicine
Junyu TaoTingjun Hu

Abstract

Polygonum hydropiper L. is widely used as a traditional remedy for the treatment of dysentery, gastroenteritis. It has been used to relieve swelling and pain, dispel wind and remove dampness, eliminate abundant phlegm and inflammatory for a long time. Previous study showed that antioxidants especially flavonoids pretreatment alleviated sepsis-induced injury in vitro and in vivo. In the present study, the possible anti-inflammatory effect of flavonoids from normal butanol fraction of Polygonum hydropiper L. extract (FNP) against inflammation induced by lipopolysaccharide (LPS) was evaluated in vivo and in vitro. The content of total flavonoid of FNP was determined by the aluminum colorimetric method. The content of rutin, quercetin and quercitrin was determined by HPLC method. Mice received FNP orally 3 days before an intra-peritoneal (i.p.) injection of lipopolysaccharide (LPS). Total superoxidase dismutase (T-SOD), total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), glutathione (GSH), myeloperoxidase (MPO) and malondialdehyde (MDA) levels were measured. Tumor necrosis factor-α levels in serum and tissue was measured. mRNA expressions of pro-inflammatory cytokines in lung were assessed by Real-Time PCR. Histopa...Continue Reading

References

Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·P Moreillon, P A Majcherczyk
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shailendra GiriInderjit Singh
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B Y de WinterP A Pelckmans
Aug 19, 2005·Current Infectious Disease Reports·Pajman Danai, Greg S Martin
Oct 19, 2005·Biochemical and Biophysical Research Communications·Jian-Hai DuYou-Yi Zhang
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert F Schwabe, David A Brenner
Feb 3, 2007·Toxicology Letters·Neelima Pathak, Shashi Khandelwal
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·Akira Murakami, Hajime Ohigashi
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chih-Hsin TangWen-Mei Fu
Dec 14, 2007·Critical Care Medicine·Sushma K Cribbs, Greg S Martin
Dec 17, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S GonzaloM D Murillo
Jan 8, 2011·Journal of Chromatography. a·Mirosław A Hawrył, Monika Waksmundzka-Hajnos
Oct 4, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A-Reum KimHyeung-Rak Kim
Dec 21, 2011·Journal of Ethnopharmacology·Yanyan YangJae Youl Cho
Feb 4, 2012·Journal of Critical Care·Tara LaguPeter K Lindenauer
Jun 21, 2012·International Immunopharmacology·Lanan Wassy SoromouXuming Deng
Aug 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sheng-lang Jin, Yong-guang Yin
Oct 27, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jun LiuChang-Hai Jin
Nov 2, 2013·Emergency Medicine Clinics of North America·Jennifer M Reifel Saltzberg
Oct 13, 2014·Environmental Toxicology and Pharmacology·Merve BacanlıNurşen Başaran

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Citations

Oct 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yu-Qiong HeWan-Sheng Chen
Sep 26, 2020·Current Topics in Medicinal Chemistry·Chen XuBan-Feng Ruan

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Methods Mentioned

BETA
MDA
enzyme-linked immuno sorbent assay
ELISA
PCR
light microscopy
protein assay

Software Mentioned

SPSS

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