Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity

Nutrition and Cancer
Jenifer I Fenton, Norman G Hord

Abstract

Colonic epithelial cell migration is required for movement up to the apex of the crypt and, hence, normal differentiated cell function. This migratory phenotype is dependent upon wild-type adenomatous polyposis coli (Apc) expression. The purpose of this study is to determine whether specific flavonoids induce cell migration in colon epithelial cells either wild type or heterozygous for Apc genotype. Nontumorigenic murine colon epithelial cell lines with distinct Apc genotypes, young adult mouse colon (YAMC; Apc+/+) cells, and Immortomouse/Min colon epithelial (IMCE; Apc(Min/+)) cells were used to assess the ability of specific flavonoids to induce cell migration relative to migration induced by hepatocyte growth factor (HGF). The citrus flavanones naringenin and hesperetin did not induce cell migration comparable with HGF in either cell type. However, the glycosylated forms of these flavanones, naringin and hesperidin, induced migration differentially in YAMC and IMCE cells. Specifically, naringin and hesperidin induced the greatest migratory response in IMCE cells at 1 microM (P < 0.01) and induced migration greater than untreated control cells (P < 0.05) but equal to HGF-treated cells. In YAMC cells, hesperidin did not induce...Continue Reading

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Dec 1, 2012·Molecular Nutrition & Food Research·Émilie C Lefort, Jonathan Blay
Jun 17, 2008·European Journal of Nutrition·Theo M de KokMargaret M Manson
May 16, 2019·Journal of Cellular Physiology·Khashayar AfshariAmir Hossein Abdolghaffari
May 10, 2006·Biochemical and Biophysical Research Communications·Russ MistyPaul A Steimle
Mar 2, 2011·Molecular Aspects of Medicine·Maria MarinoFlavia Franconi

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