Flavonoids protect pancreatic beta-cells from cytokines mediated apoptosis through the activation of PI3-kinase pathway

Cytokine
Chia-Yu LinChong-Kuei Lii

Abstract

The preventive effects of four phenolic compounds against cytokines-induced β-cell destruction were assessed in this study. Treatment of INS-1 (832/13) cells with pro-inflammatory cytokine mixtures (interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)) resulted in an increased apoptosis. While resveratrol or myricetin failed to prevent cell apoptosis, quercetin or naringenin treatment exhibited an about 40% less in cell death induced by cytokines-mediated damage. This protective effect of quercetin or naringenin might be mediated partially via the activation of the downstream pAkt and pBad pathways, an outcome which was abolished by pretreatment with a specific PI3-kinase inhibitor. Cellular protein levels of p-p38 MAPK and inducible NO synthase (iNOS) were enhanced after cytokines addition; however, the presence of quercetin or naringenin could not suppress their expression. While cytokines induced MnSOD, quercetin or naringnin did not further enhance expression of this protective protein. In addition, the loss of mitochondria membrane potential (MMP) after cytokines treatment might be partially corrected with quercetin or naringenin. However, none of the phenolic compounds tested in this study reve...Continue Reading

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Citations

Apr 1, 2014·Genes & Nutrition·Mohammad Lukman MansuriMordhwaj S Parihar
Jul 6, 2014·Pharmacognosy Magazine·Rosa Martha Perez Gutierrez, Efren Garcia Baez
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Apr 28, 2019·International Journal of Molecular Sciences·Benedetta RussoSimona Frontoni
May 9, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yeonsoo JoeHun Taeg Chung

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