PMID: 9643451Jun 27, 1998Paper

Flavonoids reduce morphine withdrawal in-vitro

The Journal of Pharmacy and Pharmacology
A CapassoL Sorrentino

Abstract

The effects of quercetin, flavone, catechin and chrysin on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum have been investigated in-vitro. After 4 min in-vitro exposure to morphine a strong contracture of guinea-pig isolated ileum was observed after the addition of naloxone. All the flavonoids, injected 10 min before morphine at concentrations between 10(-7) and 10(-5) M, were capable of blocking naloxone-induced contracture after exposure to morphine in a concentration-dependent fashion. IC50 values calculated for quercetin, flavone, catechin and chrysin were 2.7 x 10(-6), 7.3 x 10(-7), 8.5 x 10(-7) and 5.3 x 10(-6) M, respectively. These results suggest that flavonoids might play an important role in the control of morphine withdrawal.

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Citations

Sep 21, 2002·Journal of Ethnopharmacology·Thangarajan SumathiSivasithamparam Niranjali Devaraj
Sep 24, 2005·Journal of Medicinal Food·D JoshiS K Kulkarni
Sep 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Mathivadhani PanneerselvamHemal H Patel
Nov 10, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G KorteP G Sand
Jan 16, 2007·Journal of Ethnopharmacology·M E González-TrujanoF J López-Muñoz
Jul 21, 2004·Journal of Ethnopharmacology·Kamaldeep DhawanAnupam Sharma
Sep 3, 2014·European Journal of Pharmacology·Mohammad Taghi MansouriBehnam Ghorbanzadeh
Sep 18, 2003·Addiction Biology·Pattipati S NaiduShrinivas K Kulkarni
Sep 19, 2003·Phytotherapy Research : PTR·Hossein Hosseinzadeh, Mahnaz Nourbakhsh
Sep 10, 2015·Analytical Cellular Pathology (Amsterdam)·Cassia Calixto-CamposWaldiceu A Verri
Oct 31, 2000·Phytotherapy Research : PTR·A CapassoR Aquino

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