Flavonol Intake and Cognitive Decline in Middle-Aged Adults

Journal of Medicinal Food
Martin RootAnne Harper

Abstract

Cognitive decline occurs with age and may be slowed by dietary measures, including increased intake of dietary phytochemicals. However, evidence from large and long-term studies of flavonol intake is limited. Dietary intakes of flavonols were assessed from a large biracial study of 10,041 subjects, aged 45-64, by analysis of a food frequency questionnaire administered at visit 1 of triennial visits. Cognitive function was assessed at visits 2 and 4 with the following three cognitive performance tests: the delayed word recall test, the revised Wechsler Adult Intelligence Scale digit symbol subtest, and the word fluency test of the Multilingual Aphasia Examination. The change in each score over 6 years was calculated, and a combined standardized change score was calculated. Generalized linear models controlled for age, ethnicity, gender, education level, energy intake, current smoking, physical activity, body mass index, diabetes, and vitamin C intake. Total flavonols across quintiles of intake were positively associated with preserved combined cognitive function (P<.001). This pattern with preserved combined cognitive function was consistent for the three major individual flavonols in the diet, myricetin, kaempferol, and quercet...Continue Reading

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Citations

Apr 22, 2019·Biomolecules & Therapeutics·Hyun LimHyun Pyo Kim
Jun 14, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Chiara Colizzi
Jan 29, 2021·Protein and Peptide Letters·Aline M Hilzendeger Zilli, Eduardo M Zilli
Sep 25, 2018·Lancet Neurology·Nikolaos ScarmeasMary Yannakoulia

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