Feb 1, 1975

Flavoxate, a potent phosphodiesterase inhibitor

Archives Internationales De Pharmacodynamie Et De Thérapie
M Conti, I Setnikar

Abstract

The c-AMP phosphodiesterase inhibiting properties of flavoxate and of its main metabolite i.e. 3-methylflavone-8-carboxylic acid (MFCA), were assayed in vitro and compared to those of theophylline. Flavoxate and MFCA are competitive phosphodiesterase inhibitors, and are 21 and respectively 5 times more potent than theophylline. The smooth muscle relaxing activity of flavoxate possibly relies on this enzymatic mechanism.

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Mentioned in this Paper

Phosphodiesterase Inhibitors
Bioflavonoids
Myocardium
Piperidines
Monospan
Bos indicus

About this Paper

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