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Flaw or discovery? Calculating exact p-values for genome-wide association studies in inbred populations

bioRxiv

Feb 17, 2015

Xia Shen

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Abstract

Motivation: Genome-wide association studies have been conducted in inbred populations where the sample size is small. The ordinary association p-values and multiple testing correction therefore become questionable, as the detected genetic effect may or may not be due to chance, dependin...read more

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Simulation
Population Group
Inbred Strain
Genome
MAF Protein
Motivation
Arabidopsis thaliana <plant>
Genome-Wide Association Study
Research Study
Structure
8
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  • Flaw or discovery? Calculating exact p-values for genome-wide association studies in inbred populations

    bioRxiv

    Feb 17, 2015

    Xia Shen

    PMID: 990015339

    DOI: 10.1101/015339

    Abstract

    Motivation: Genome-wide association studies have been conducted in inbred populations where the sample size is small. The ordinary association p-values and multiple testing correction therefore become questionable, as the detected genetic effect may or may not be due to chance, dependin...read more

    Mentioned in this Paper

    Simulation
    Population Group
    Inbred Strain
    Genome
    MAF Protein
    8

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