Flax Fiber Hydrophobic Extract Inhibits Human Skin Cells Inflammation and Causes Remodeling of Extracellular Matrix and Wound Closure Activation

BioMed Research International
Monika StyrczewskaJan Szopa

Abstract

Inflammation is the basis of many diseases, with chronic wounds amongst them, limiting cell proliferation and tissue regeneration. Our previous preclinical study of flax fiber applied as a wound dressing and analysis of its components impact on the fibroblast transcriptome suggested flax fiber hydrophobic extract use as an anti-inflammatory and wound healing preparation. The extract contains cannabidiol (CBD), phytosterols, and unsaturated fatty acids, showing great promise in wound healing. In in vitro proliferation and wound closure tests the extract activated cell migration and proliferation. The activity of matrix metalloproteinases in skin cells was increased, suggesting activation of extracellular components remodeling. The expression of cytokines was diminished by the extract in a cannabidiol-dependent manner, but β-sitosterol can act synergistically with CBD in inflammation inhibition. Extracellular matrix related genes were also analyzed, considering their importance in further stages of wound healing. The extract activated skin cell matrix remodeling, but the changes were only partially cannabidiol- and β-sitosterol-dependent. The possible role of fatty acids also present in the extract is suggested. The study shows t...Continue Reading

References

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Feb 1, 2011·BMC Biotechnology·Magdalena ZukJan Szopa
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Aug 11, 2012·Life Sciences·Amr A FouadIyad Jresat

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Citations

Aug 9, 2018·Phytotherapy Research : PTR·Mariana KleinMaria Antonia Zancanaro de Figueiredo
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kinga Fanni TóthAttila Oláh
Jul 25, 2019·Current Pharmaceutical Design·Monika StyrczewskaAnna Kulma
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Tomasz GębarowskiKazimierz Gąsiorowski
Apr 15, 2021·Planta medica·Giulia MartinelliEnrico Sangiovanni
Jul 15, 2021·Fundamental & Clinical Pharmacology·Inês Correia-SáMaria A Vieira-Coelho

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Methods Mentioned

BETA
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PCR

Software Mentioned

STATISTICA
TScratch
Chemstation

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