Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

Renal Failure
Sameer H Sawant, Subhash L Bodhankar

Abstract

Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from the seeds of Linum usitatissimum L. (Linaceae). To investigate the effect of FLC in deoxycorticosterone acetate (DOCA)-salt induced experimental renal hypertension in rats. Hypertension was induced in uninephrectomized (UNTZD) male Wistar rats (230-280 g) by injecting DOCA (25 mg/kg, subcutaneously, twice weekly) and supplementing 1% NaCl in drinking water for 5 weeks. The rats were divided in six groups. Captopril (30 mg/kg, p.o.) and FLC (200, 400 and 800 mg/kg, p.o.) were administered daily to the rats of groups III-VI, respectively, for 5 weeks. Various hemodynamic and biochemical parameters were investigated as well as histology of kidney and heart were carried out. In this study, the FLC (400 and 800 mg/kg) significantly (p < 0.01, p < 0.001) decreased the systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure. It also significantly (p < 0.01, p < 0.001) decreased elevated end diastolic pressure (EDP), dP/dt max and dP/dt min, organs weights (kidney and heart) and activities of hepatic, renal and cardiac marker enzymes in the serum. Furthermore, FLC (400 an...Continue Reading

References

Jun 1, 1975·The American Journal of Physiology·J MöhringS Kazda
May 1, 1992·Journal of Pharmacological and Toxicological Methods·J Schenk, J H McNeill
Oct 1, 1992·The New England Journal of Medicine·E D FrohlichB Massie
Nov 1, 1972·The American Journal of Medicine·P J Mulrow, B H Forman
Nov 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·J MairG Michel
Aug 1, 1993·Planta medica·M Concepción NavarroM Pilar Utrilla
Sep 11, 2002·Obstetrics and Gynecology·André LemayJean-Claude Forest
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thomas F X CollinsDennis I Ruggles
Sep 15, 2004·American Journal of Hypertension·Bernard Lassègue, Kathy K Griendling
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Andrew FenningLindsay Brown
May 25, 2006·Journal of Agricultural and Food Chemistry·J RajeshaGokare A Ravishankar
Jun 20, 2006·British Journal of Pharmacology·Vincent ChanLindsay Brown
Apr 7, 2007·American Journal of Therapeutics·María Cristina Armas-PadillaManuel Valasco
Nov 15, 2007·Nitric Oxide : Biology and Chemistry·Alexander HoetzelBenedikt H J Pannen
Dec 15, 2007·Endocrinology·Fumiko IwashimaYukio Hirata
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Nandini BhattacharjeeAnisur Rahman Khuda-Bukhsh
Jan 14, 2011·Lancet·Vikram PatelK Srinath Reddy
Nov 2, 2011·Current Cardiology Reviews·Abishek IyerLindsay Brown
Feb 22, 2012·Inflammopharmacology·Kiran S RaygudeSubhash L Bodhankar
May 12, 2012·Asian Pacific Journal of Tropical Medicine·Chinnadurai VeeramaniKodukkur Viswanathan Pugalendi
Oct 13, 2012·Fundamental & Clinical Pharmacology·Amit D KandhareSubhash L Bodhankar
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·P PrahalathanB Raja
Apr 12, 2013·Molecular and Cellular Biochemistry·Govindasamy HemalathaRamalingam Saravanan
Jan 18, 2014·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Kailash Prasad
Apr 3, 2014·International Wound Journal·Saurabh GoswamiRavindran Kharat

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May 28, 2019·Nutrients·Mihir ParikhGrant N Pierce

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