Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women

The Journal of Clinical Endocrinology and Metabolism
Edralin A LucasBahram H Arjmandi

Abstract

The risk of cardiovascular disease and osteoporosis drastically increases at the onset of menopause. Phytoestrogens have been suggested to inhibit bone loss and protect the cardiovascular system, in part by improving lipid profiles. The purpose of the present study was to examine the effects of flaxseed, a rich source of the phytoestrogens called lignans, on lipid metabolism and biomarkers of bone turnover in postmenopausal women. Postmenopausal women who were not on hormone replacement therapy were assigned to one of two treatment groups in a double-blind randomized study. Women were asked to consume 40 g of either ground flaxseed or wheat-based comparative control regimen daily for 3 months. In addition, all subjects received 1,000 mg calcium and 400 IU vitamin D daily. Flaxseed supplementation lowered (P < 0.05) both serum total cholesterol and non-high-density lipoprotein cholesterol by 6%, whereas the comparative control regimen had no such effect. Flaxseed regimen reduced serum levels of both low-density- and high-density-lipoprotein cholesterol by 4.7% and triglyceride by 12.8%, albeit not statistically significant. Serum apolipoprotein A-1 and apolipoprotein B concentrations were significantly (P < 0.005) reduced by 6 a...Continue Reading

Associated Clinical Trials

Mar 29, 2013·Dr. Heather Blewett

References

Jan 1, 1991·Nutrition and Cancer·L U ThompsonF Cheung
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Oct 1, 1984·Journal of Personality Assessment·T Millon
Jan 1, 1995·The American Journal of Clinical Nutrition·S C CunnaneD J Jenkins
Oct 1, 1993·Journal of the American College of Nutrition·M L BierenbaumT R Watkins
Mar 1, 1993·The British Journal of Nutrition·S C CunnaneD J Jenkins
Jun 25, 1996·Biochemical and Biophysical Research Communications·H ManoM Kumegawa
Jan 1, 1996·Nutrition and Cancer·L U ThompsonH H Fong
Dec 16, 1998·The American Journal of Clinical Nutrition·S M PotterJ W Erdman
Jan 30, 1999·The American Journal of Clinical Nutrition·L BrownF M Sacks
Mar 20, 1999·The Journal of Nutrition·K D Setchell, A Cassidy
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A M DuncanM S Kurzer
Jun 6, 2000·The American Journal of Clinical Nutrition·J W AndersonK W Weingand
Jul 13, 2000·Plant Foods for Human Nutrition·A C Frias, V C Sgarbieri
Jul 29, 2000·Menopause : the Journal of the North American Menopause Society
Aug 23, 2000·International Journal of Food Sciences and Nutrition·U S BabuH Gowda
Nov 4, 2000·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·K Prasad
Dec 21, 2000·Current Atherosclerosis Reports·P J Jones
Jul 13, 2001·Menopause : the Journal of the North American Menopause Society·P B Clifton-BlighT Moreton

❮ Previous
Next ❯

Citations

Jun 12, 2009·The American Journal of Clinical Nutrition·An PanXu Lin
May 23, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sandra M SaccoWendy E Ward
May 7, 2011·Climacteric : the Journal of the International Menopause Society·M Gossell-WilliamsC A Walters
Jul 19, 2011·Progress in Lipid Research·Hemant PoudyalLindsay Brown
Dec 2, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A A TroinaM C F Passos
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Lorraine A Fitzpatrick
Dec 6, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Annalidia SammartinoCarmine Nappi
Mar 24, 2004·Integrative Cancer Therapies·Colleen E Piersen
Apr 12, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Carlo Stuglin, Kailash Prasad
Oct 19, 2006·The Annals of Pharmacotherapy·Leslie K NiesKari L Olson
Jun 6, 2015·Journal of Menopausal Medicine·Mi Young KimAeli Ryu
Jan 15, 2019·Journal of Cellular Physiology·Amir Abbas Momtazi-BorojeniAmirhossein Sahebkar
Sep 17, 2003·Current Diabetes Reports·Jo Ann S Carson
Mar 5, 2004·Nutrition Reviews·LeAnne T Bloedon, Philippe O Szapary
Apr 2, 2019·Analytical and Bioanalytical Chemistry·Xi-Yu PanTsung-Rong Kuo
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·C M C DupasquierG N Pierce
Dec 17, 2009·The British Journal of Nutrition·Jennifer L AdolpheJane Alcorn
Mar 17, 2004·The Proceedings of the Nutrition Society·Francesco Branca
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Sara C CampbellBahram H Arjmandi
Apr 11, 2013·Menopause : the Journal of the North American Menopause Society·Tristan P Dew, Gary Williamson
Jun 22, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohammadi-SartangJ O Totosy de Zepetnek
Oct 13, 2015·Journal of the Science of Food and Agriculture·Motoi TamuraTakuya Sugahara
Feb 3, 2009·Menopause : the Journal of the North American Menopause Society·Sandra M SaccoWendy E Ward
Apr 17, 2008·The Proceedings of the Nutrition Society·Véronique Coxam
Feb 23, 2018·Frontiers in Nutrition·Ana CaladoPaula Ravasco
Aug 12, 2020·Phytotherapy Research : PTR·Jéssica C P Petrine, Bruno Del Bianco-Borges
Jan 6, 2004·The Journal of Nutrition·Aynun Nahar BegumAugustin Scalbert
Mar 17, 2016·Advances in Nutrition·Amanda B Longo, Wendy E Ward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.