Flaxseed Oil Attenuates Hepatic Steatosis and Insulin Resistance in Mice by Rescuing the Adaption to ER Stress

Journal of Agricultural and Food Chemistry
Xiao YuXuyan Dong

Abstract

Increasing evidence has demonstrated the benefits of α-linolenic acid-rich flaxseed oil (ALA-FO) against lipid metabolism abnormality in both rodent models and humans. However, the metabolic response of FO to insulin resistance and type 2 diabetes is still inconsistent. This study aimed to explore the effect of FO on chronic high fat diet (HFD)-induced hepatic steatosis, insulin resistance, and inflammation, mainly focusing on hepatic n-3 fatty acid remodeling and endoplasmic reticulum (ER) unfolded protein response. The results showed that lard-based HFD feeding for 16 weeks (60% fat-derived calories) induced whole-body insulin resistance, lipid profile abnormality, and inflammation in mice, which was alleviated by FO in a dose-dependent manner. Moreover, FO effectively improved hepatic steatosis and insulin resistance in mice by modulating the specific location of ALA and its long-chain n-3 fatty acids across hepatic lipid fractions and enhancing insulin-stimulated phosphorylation of hepatic insulin receptor subtract-1 (IRS-1) tyrosine 632 and protein kinase B (AKT) ( p < 0.05). Importantly, the differential depositions of ALA and its long-chain n-3 fatty acids in plasma and ER membranes were observed, concomitant with the re...Continue Reading

References

Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Dec 12, 2007·Biochemical and Biophysical Research Communications·Kazutomi YoshiuchiMunehide Matsuhisa
Dec 1, 2009·Cell Metabolism·Guadalupe SabioRoger J Davis
Jun 4, 2010·Cell Metabolism·Ling YangGökhan S Hotamisligil
Mar 11, 2011·Critical Reviews in Food Science and Nutrition·K K SinghP Barnwal
Jan 27, 2012·The Journal of Nutrition·Philip C Calder
Apr 21, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Harmony F Turk, Robert S Chapkin
May 9, 2012·Cell Metabolism·Suneng FuGökhan S Hotamisligil
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Romain VolmerDavid Ron
Jun 12, 2013·Canadian Journal of Physiology and Pharmacology·Jessica MonteiroDavid W L Ma
Jan 18, 2014·Nature Protocols·Jan M SuskiMariusz R Wieckowski
Mar 27, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Su-Yeon LeeTae-Sik Park
Apr 22, 2015·International Journal of Biological Sciences·Quan ZhangLu Cai
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Sep 18, 2015·Seminars in Liver Disease·Sanjaya K Satapathy, Arun J Sanyal
Oct 16, 2015·The Journal of Endocrinology·Hamza AmineMohammed Taouis
Jul 10, 2016·Mechanisms of Ageing and Development·Perinur BozaykutNesrin Kartal Ozer

❮ Previous
Next ❯

Citations

Apr 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chunjie JiangPing Yao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.