Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice

The British Journal of Nutrition
D S KelleyB E Mackey

Abstract

Insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) are found in 35 and 30 % of US adults, respectively. Trans-10, cis-12-conjugated linoleic acid (CLA) has been found to cause both these disorders in several animal models. We hypothesised that IR and NAFLD caused by CLA result from n-3 fatty acid deficiency. Pathogen-free C57BL/6N female mice (aged 8 weeks; n 10) were fed either a control diet or diets containing trans-10, cis-12-CLA (0.5 %) or CLA+flaxseed oil (FSO) (0.5 %+0.5 %) for 8 weeks. Weights of livers, concentration of circulating insulin, values of homeostatic model 1 (HOMA1) for IR and HOMA1 for beta cell function were higher by 160, 636, 985 and 968 % in the CLA group compared with those in the control group. FSO decreased fasting glucose by 20 % and liver weights by 37 % compared with those in the CLA group; it maintained circulating insulin, HOMA1-IR and HOMA1 for beta cell function at levels found in the control group. CLA supplementation decreased n-6 and n-3 wt% concentrations of liver lipids by 57 and 73 % and increased the n-6:n-3 ratio by 58 % compared with corresponding values in the control group. FSO increased n-6 and n-3 PUFA in liver lipids by 33 and 342 % and decreased the n-6:n-3 r...Continue Reading

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Citations

May 25, 2012·The British Journal of Nutrition·Jason H Y WuDariush Mozaffarian
Sep 19, 2009·Nutrition & Metabolism·Sailas Benjamin, Friedrich Spener
Sep 6, 2013·European Journal of Nutrition·Christian-Alexandre CastellanoJ Jacques Matte
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Apr 11, 2019·Current Medicinal Chemistry·Rodrigo ValenzuelaLuis Alberto Videla

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