Flecainide suppresses defibrillator-induced storming in catecholaminergic polymorphic ventricular tachycardia

Pacing and Clinical Electrophysiology : PACE
Robert A HongJoon J Choi

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition associated with ventricular tachycardia (VT) triggered by exercise or sympathetic stress. Incessant VT may develop due to defibrillator-induced storming-a condition where implantable cardioverter-defibrillator discharges result in a hyperadrenergic state, provoking further VT and defibrillator discharge. We describe the case of a 14-year-old boy with CPVT caused by a calsequestrin-2 mutation, who presented with defibrillator-induced storming refractory to β-blockers, calcium-channel blockers, amiodarone, and dronedarone. Flecainide and β-blocker use suppressed incessant VT and defibrillator-induced storming.

References

May 2, 2002·Cardiac Electrophysiology Review·Philippe Coumel
May 9, 2008·The New England Journal of Medicine·Arthur A M WildePeter J Schwartz
Aug 8, 2008·Pacing and Clinical Electrophysiology : PACE·Sam de la FuenteAlbert Meijer
Mar 31, 2009·Nature Medicine·Hiroshi WatanabeBjörn C Knollmann
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May 28, 2011·Journal of the American College of Cardiology·Christian van der WerfArthur A M Wilde

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Citations

Apr 4, 2013·European Journal of Human Genetics : EJHG·Carlo NapolitanoSilvia Giuliana Priori
Sep 8, 2012·Current Opinion in Pediatrics·Frank A Fish, Prince J Kannankeril
Jun 1, 2013·Cardiology and Therapy·Eric S Williams, Mohan N Viswanathan
Jul 31, 2012·Journal of Electrocardiology·Arthur A M Wilde, Christian van der Werf
Dec 21, 2012·Pacing and Clinical Electrophysiology : PACE·Henning ClausenAndrew Davis
May 24, 2016·Annals of Pediatric Cardiology·Shashank P Behere, Steven N Weindling
Jul 1, 2017·Current Heart Failure Reports·Kenneth Varian, W H Wilson Tang

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