PMID: 1686009Jan 1, 1991

Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice

Fundamental & Clinical Pharmacology
J DuteilE Assous


The potential antidepressant effect of flerobuterol (dl-(fluoro-2 phenyl)-1 t-butylamino-2 ethanol), a new drug related to beta-adrenoceptor agonists, was evaluated and compared with imipramine and salbutamol using classical psychopharmacological tests in mice. Like imipramine and salbutamol, flerobuterol (0.5-32 mg kg-1, ip) fully prevented apomorphine (16 mg kg-1, sc)- and partly reversed reserpine- and oxotremorine-induced hypothermia. At higher doses (16-32 mg kg-1), flerobuterol enhanced the toxic effects of yohimbine. Unlike imipramine, flerobuterol and salbutamol did not reduce immobility duration in the behavioural despair test. Salbutamol and flerobuterol decreased locomotor activity. Flerobuterol did not induce mydriasis, did not prevent oxotremorine-induced tremors or salivary and lacrimal gland secretion and did not reduce reserpine-induced palpebral ptosis. Propranolol (8 mg kg-1, ip) but not alpha-methyl-paratyrosine (75 mg kg-1, ip) prevented the flerobuterol-induced antagonism of apomorphine-induced hypothermia. Our results suggest that flerobuterol demonstrates potential antidepressant activity, which could be related to beta-adrenoceptor activation in mice.


Mar 1, 1978·Pharmacological Research Communications·H F Simon
Mar 1, 1979·Pharmacological Research Communications·H FrancèsP Simon
Oct 8, 1977·Lancet·D WidlöcherP Simon
Nov 23, 1979·European Journal of Pharmacology·M SoutoP Simon
Oct 1, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Jan 1, 1978·European Journal of Pharmacology·A J PuechP Simon
Aug 1, 1990·The Journal of Pharmacy and Pharmacology·G VolterraA Meli
Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·H FrancesP Simon
Sep 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H Francès
Apr 1, 1974·Computers and Biomedical Research, an International Journal·A Alperovitch, J Lellouch
Jan 1, 1969·British Journal of Pharmacology·V A CullumG P Levy
Nov 1, 1980·Acta Pharmacologica Et Toxicologica·S B Ross
Aug 1, 1984·Pharmacology, Biochemistry, and Behavior·P L GoldschmidtP Simon
May 1, 1980·Neuropharmacology·M M Sellinger-BarnetteA Frazer
Apr 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·Y LecrubierD Widlocher
Mar 1, 1953·British Journal of Pharmacology and Chemotherapy·P B DEWS
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·R M QUINTON


Aug 28, 2004·CNS Drugs·Fokko J BoskerJakob Korf
Apr 11, 2018·The International Journal of Neuropsychopharmacology·Dominique VodovarMathieu Charvériat

Related Concepts

Flerobuterol hydrochloride
Adrenergic beta-Agonists
Behavior, Animal
Drug Interactions
Hypothermia, Accidental

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