Mar 30, 2020

Multimodal brain imaging study of 19,825 participants reveals adverse effects of moderate drinking

BioRxiv : the Preprint Server for Biology
Francis GaudreaultReagan Wetherill


Alcohol consumption can have significant deleterious consequences, including brain atrophy, neuronal loss, poorer white matter fiber integrity, and cognitive decline, but the effects of light-to-moderate alcohol consumption on brain structure remain unclear. Here we examine the associations between alcohol intake and brain structure using structural, diffusion tensor, and neurite orientation dispersion and density imaging data from 19,825 generally healthy middle-aged and older adults from the UK Biobank. Systematically controlling for potential confounds, we found that greater alcohol consumption was associated with lower global gray and white matter volume, regional gray matter volume in cortical and subcortical areas, and white matter fiber integrity and complexity. Post hoc analyses revealed that these associations were non-linear. Our findings extensively characterize the associations between alcohol intake and gray and white matter macrostructure and microstructure. Consuming two or more units of alcohol per day, equivalent to one drink in some establishments, could have negative effects on brain health, an important public health finding.

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Bounded by
Ligand Binding
DOCK6 protein, human
Complex (molecular entity)
Integrator, veterinary brand name drug
Docking -molecular Interaction
Signal Pathways
Biochemical Reaction
Binding (Molecular Function)

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