Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins.

The Journal of Biological Chemistry
Sarah E BondosKathleen S Matthews

Abstract

To modulate transcription, a variety of input signals must be sensed by genetic regulatory proteins. In these proteins, flexibility and disorder are emerging as common themes. Prokaryotic regulators generally have short, flexible segments, whereas eukaryotic regulators have extended regions that lack predicted secondary structure (intrinsic disorder). Two examples illustrate the impact of flexibility and disorder on gene regulation: the prokaryotic LacI/GalR family, with detailed information from studies on LacI, and the eukaryotic family of Hox proteins, with specific insights from investigations of Ultrabithorax (Ubx). The widespread importance of structural disorder in gene regulatory proteins may derive from the need for flexibility in signal response and, particularly in eukaryotes, in protein partner selection.

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Citations

Jun 14, 2016·Current Opinion in Structural Biology·Ngaio C Smith, Jacqueline M Matthews
Jan 17, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Miguel Ortiz-LombardiaYacine Graba
Feb 2, 2017·Proteomics·David-Paul MindeKathryn S Lilley
Apr 22, 2017·Nature Communications·Hallel I SchreierNaama Brenner
Jan 11, 2018·Protein Science : a Publication of the Protein Society·Joseph S XuKathleen S Matthews
Jul 14, 2017·The Biochemical Journal·Lasse StabyKaren Skriver
Sep 2, 2016·Journal of Developmental Biology·Arya Zandvakili, Brian Gebelein
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Jul 12, 2017·Computational and Structural Biotechnology Journal·Anne Grove
Jul 19, 2017·Biochemistry·Jingheng WangSilvina Matysiak

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