PMID: 1833043Sep 1, 1991

Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma

Cancer
B DamascelliF Radice

Abstract

Complete and lasting control of diffuse metastases from a renal cell carcinoma has been achieved by automatic continuous infusion of a single cytotoxic agent, fluorodeoxyuridine (FUDR). A patient with a single brain metastasis from renal cell carcinoma developed pulmonary, mediastinal, and retroperitoneal metastases after radical nephrectomy. A Medtronic Synchromed pump (Medtronic Inc., Minneapolis, MN) was implanted for the circadian systemic infusion of FUDR in 14-day courses with 14-day drug-free intervals. A complete response (CR) at all sites, was obtained in 3 months, and maintained for 22 months. After a second brain metastasis, treated by radiation therapy and cisplatin as radiosensitizer, a CR was obtained again and is now of 31 months' duration, which is four times the record to date. The overall hospitalization was 2 days. Acceptance of the pump is excellent and it functions precisely and reliably. This case should stimulate greater interest in techniques of automatic continuous infusion of cytostatics, given its greater efficacy and lower toxicity.

References

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Citations

Apr 1, 1995·Seminars in Roentgenology·S B Malkowicz
Oct 18, 2002·Advanced Drug Delivery Reviews·Paul P WangH Brem
Dec 1, 1995·Neurosurgery·K A WalterH Brem
May 16, 2006·The Journal of Laboratory and Clinical Medicine·Keith M SkubitzAmy P N Skubitz
Jul 21, 2005·Technology in Cancer Research & Treatment·Maciej S Lesniak

Related Concepts

Brain Tumor, Recurrent
Chromophobe Renal Cell Carcinoma
Circadian Rhythms
Drug Administration Schedule
Drug Evaluation
Floxuridine
Malignant Neoplasm of Kidney
Medication Systems, Programmable Implantable

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