Flexible and Tunable 3D Gold Nanocups Platform as Plasmonic Biosensor for Specific Dual LSPR-SERS Immuno-Detection

Scientific Reports
Monica FocsanSimion Astilean

Abstract

Early medical diagnostic in nanomedicine requires the implementation of innovative nanosensors with highly sensitive, selective, and reliable biomarker detection abilities. In this paper, a dual Localized Surface Plasmon Resonance - Surface Enhanced Raman Scattering (LSPR- SERS) immunosensor based on a flexible three-dimensional (3D) gold (Au) nanocups platform has been implemented for the first time to operate as a relevant "proof-of-concept" for the specific detection of antigen-antibody binding events, using the human IgG - anti-human IgG recognition interaction as a model. Specifically, polydimethylsilane (PDMS) elastomer mold coated with a thin Au film employed for pattern replication of hexagonally close-packed monolayer of polystyrene nanospheres configuration has been employed as plasmonic nanoplatform to convey both SERS and LSPR readout signals, exhibiting both well-defined LSPR response and enhanced 3D electromagnetic field. Synergistic LSPR and SERS sensing use the same reproducible and large-area plasmonic nanoplatform providing complimentary information not only on the presence of anti-human IgG (by LSPR) but also to identify its specific molecular signature by SERS. The development of such smart flexible healthca...Continue Reading

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Citations

Dec 14, 2019·The Analyst·Juanjuan LiuSebastian Wachsmann-Hogiu
Sep 14, 2018·Sensors·Laurentiu SusuMonica Focsan
Feb 6, 2019·Scientific Reports·Zahra KhajemiriDai-Sik Kim
Apr 3, 2020·Micromachines·Muqsit Pirzada, Zeynep Altintas
May 8, 2018·Trends in Analytical Chemistry : TRAC·Hedieh MalekzadMichael R Hamblin
Jun 12, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hyeong-Min KimSeung-Ki Lee
Jun 15, 2021·Biomedical Optics Express·Charles Soon Hong HwangKi-Hun Jeong
Dec 22, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Marziye MirbagheriDae Kun Hwang
Oct 27, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Sravani Kaja, Amit Nag

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biosensors
ELISA
biosensor
biosensing
chips
scanning electron imaging
atomic force microscopy
AFM
surface plasmon resonances

Software Mentioned

FDTD Solutions

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