Flexible freestanding graphene paper-based potentiometric enzymatic aptasensor for ultrasensitive wireless detection of kanamycin

Biosensors & Bioelectronics
Yao YaoJianfeng Ping

Abstract

Flexible sensing devices have drawn tremendous attention in the past decades due to their potential applications in future hand-held, potable consumer, and wearable electronics. Here, we firstly developed an ultrasensitive wireless potentiometric aptasensor based on flexible freestanding graphene paper for kanamycin detection. Flexible graphene paper made from a simple vacuum filtration method was used as a biocompatible platform for effective immobilization of aptamer. A nuclease-assisted amplification strategy was introduced into this potentiometric biosensing system in order to significantly improve the detection sensitivity through a classic catalytic recycling reaction of target induced by the nuclease (DNase I). As expected, an ultra-low detection limit of 30.0 fg/mL for kanamycin was achieved. Furthermore, the developed potentiometric enzymatic aptasensor exhibits high selectivity, favorable flexibility, excellent stability and reproducibility, which holds great promising for its routine sensing application.

Citations

Jun 18, 2020·Frontiers in Chemistry·Erin M McConnellYingfu Li
Sep 18, 2020·Analytical and Bioanalytical Chemistry·Mandana AmiriReyhaneh Sadat Saberi
Oct 31, 2020·The Science of the Total Environment·Fengling YueXia Sun
Jul 7, 2020·The Science of the Total Environment·Chao ZhangYibin Ying
Oct 7, 2020·Biosensors & Bioelectronics·Tao MingXinxia Cai
Dec 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tamanna IslamA J Saleh Ahammad
Jun 15, 2021·Chemical Reviews·Eka NovianaCharles S Henry
Jul 7, 2021·Colloids and Surfaces. B, Biointerfaces·Soraya Mozafari VananiBehnaz Saffar

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