PMID: 11914186Mar 27, 2002Paper

Flexible matching strategies to increase power and efficiency to detect and estimate gene-environment interactions in case-control studies

American Journal of Epidemiology
Til Stürmer, Hermann Brenner

Abstract

Lack of power is a pertinent problem in many case-control studies of gene-environment interactions. The authors recently introduced the concept of flexible matching strategies with varying proportions of a matching factor among selected controls (degree of matching) to increase the power and efficiency of case-control studies. In this study, they extended the concept of flexible matching strategies to the field of gene-environment interactions. They assessed the power and efficiency of such studies to detect and estimate gene-environment interactions under a variety of assumptions regarding the prevalence and effects of the environmental exposure and the genetic susceptibility as well as their association in the population. For each set of parameters, 10,000 case-control studies were simulated using varying degrees of matching. Traditional frequency matching increased the power and precision in most scenarios, but even greater gains were often obtained by increasing the prevalence of the environmental exposure in controls above the one in cases. The authors concluded that flexible matching strategies can increase the power and efficiency of case-control studies to detect and estimate gene-environment interactions compared with ...Continue Reading

Citations

Jan 16, 2004·Experimental Gerontology·Hermann BrennerChristoph Rott
Sep 11, 2004·Journal of Clinical Epidemiology·N Andrieu, A M Goldstein
Oct 19, 2007·PLoS Medicine·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Mar 5, 2004·American Journal of Public Health·Kevin L Delucchi
Oct 17, 2007·Annals of Internal Medicine·Jan P VandenbrouckeUNKNOWN STROBE initiative
Mar 3, 2009·Gaceta sanitaria·Jan P VandenbrouckeUNKNOWN Iniciativa STROBE
Sep 15, 2005·Annals of Epidemiology·Nadine AndrieuAlisa M Goldstein
Sep 3, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah L KernsSøren M Bentzen
Jul 22, 2014·International Journal of Surgery·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Dec 1, 2007·Epidemiology·Jan P VandenbrouckeUNKNOWN STROBE Initiative
Apr 13, 2018·European Journal of Epidemiology·Sander GreenlandMohammad Ali Mansournia
Dec 3, 2021·Emerging Infectious Diseases·Nora CheaCheri T Grigg

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