Flexible numerical simulation framework for dynamic PET-MR data

Physics in Medicine and Biology
Johannes MayerChristoph Kolbitsch

Abstract

This paper presents a simulation framework for dynamic PET-MR. The main focus of this framework is to provide motion-resolved MR and PET data and ground truth motion information. This can be used in the optimisation and quantitative evaluation of image registration and in assessing the error propagation due to inaccuracies in motion estimation in complex motion-compensated reconstruction algorithms. Contrast and tracer kinetics can also be simulated and are available as ground truth information. To closely emulate medical examination, input and output of the simulation are files in standardised open-source raw data formats. This enables the use of existing raw data as a template input and ensures seamless integration of the output into existing reconstruction pipelines. The proposed framework was validated in PET-MR and image registration applications. It was used to simulate a FDG-PET-MR scan with cardiac and respiratory motion. Ground truth motion information could be utilised to optimise parameters for PET and synergistic PET-MR image registration. In addition, a free-breathing dynamic contrast enhancement (DCE) abdominal scan of a patient with hepatic lesions was simulated. In order to correct for breathing motion, a motion...Continue Reading

References

Sep 1, 1992·Nuclear Medicine Communications·A Todd-PokropekF Deconinck
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K P PruessmannP Boesiger
Apr 29, 2003·IEEE Transactions on Medical Imaging·Julia A SchnabelDavid J Hawkes
Sep 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P G BatchelorD Larkman
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Mar 16, 2007·Medical Image Computing and Computer-assisted Intervention : MICCAI·Daniel RueckertAlexander Hammers
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael LustigJohn M Pauly
Jan 22, 2008·Nature Structural & Molecular Biology·Matthew L CheeverJohn Sondek
Apr 9, 2008·Seminars in Nuclear Medicine·Sadek A Nehmeh, Yusuf E Erdi
Mar 7, 2009·Physics in Medicine and Biology·Richard CastilloThomas Guerrero
Oct 13, 2009·Computer Methods and Programs in Biomedicine·Marc ModatSébastien Ourselin
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Claudia PrietoTobias Schaeffter
Oct 23, 2010·Medical Physics·W P SegarsB M W Tsui
Jul 2, 2011·Physics in Medicine and Biology·Quansheng XuDatian Ye
Sep 23, 2011·Physics in Medicine and Biology·C TsoumpasP K Marsden
Nov 15, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gaspar DelsoSibylle I Ziegler
Feb 1, 2012·Physics in Medicine and Biology·Kris ThielemansMatthew W Jacobson
Jul 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael Schacht Hansen, Thomas Sangild Sørensen
Nov 6, 2012·Medical Image Analysis·J R McClellandA P King
Sep 11, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Lukas WissmannSebastian Kozerke
Dec 6, 2014·Magnetic Resonance Imaging Clinics of North America·David M Naeger, Spencer C Behr
Jan 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Maxim ZaitsevMichael Herbst
Oct 17, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mathieu RubeauxPiotr J Slomka
Jan 30, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Souheil J InatiMichael S Hansen
Mar 24, 2016·Physics in Medicine and Biology·Beverley F HolmanKris Thielemans
Jun 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kelvin J LaytonMaxim Zaitsev
Dec 3, 2016·Medical Physics·Christopher M RankMarc Kachelrieß
Jan 24, 2017·IEEE Transactions on Medical Imaging·Fang LiuAlexey A Samsonov
Feb 12, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christoph KolbitschTobias Schaeffter
Apr 21, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Camila MunozClaudia Prieto
Aug 12, 2017·Medical Image Analysis·Thomas KüstnerN F Schwenzer
Feb 7, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexandre FortinEmmanuel Durand
Mar 14, 2018·IEEE Transactions on Medical Imaging·Irene PolycarpouCharalampos Tsoumpas
Nov 6, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wei-Ching LoNicole Seiberlich
Nov 15, 2018·Physics in Medicine and Biology·Philip M RobsonZahi A Fayad
Feb 16, 2019·IEEE Transactions on Radiation and Plasma Medical Sciences·W Paul SegarsEhsan Samei
May 18, 2019·PloS One·Christos G Xanthis, Anthony H Aletras
Jun 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matteo IppolitiChristoph Kolbitsch
Jul 31, 2019·EJNMMI Physics·Parisa KhateriGünther Dissertori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Camila MunozClaudia Prieto
© 2021 Meta ULC. All rights reserved