Flexible sigmoidoscopy in colorectal cancer screening: implications of different colonoscopy referral strategies

European Journal of Epidemiology
Tobias NiedermaierHermann Brenner

Abstract

Flexible sigmoidoscopy (FS) screening reduces colorectal cancer incidence and mortality. Its potential to detect proximal neoplasms depends on colonoscopy referral. We estimated diagnostic performance of sigmoidoscopy using 12 different referral criteria in detecting colorectal cancer and advanced adenomas. Colonoscopy results from 14,947 participants of screening colonoscopy in Germany were used to derive sensitivity of sigmoidoscopy for colorectal cancer, advanced adenomas (AAs), and any advanced neoplasms in the proximal colon. It was assumed that FS detects the same neoplasms as colonoscopy within its reach and that distal neoplasms would be followed by colonoscopy. In addition, numbers of colonoscopies needed (NCN) to detect one proximal advanced neoplasm were calculated. The most advanced findings during colonoscopy were colorectal cancer in 213 subjects (1.4%), AA in 1539 subjects (10.2%) and non-advanced adenomas in 2988 subjects (19.8%). Without colonoscopy referral, overall sensitivities for any colorectal cancer, advanced adenoma and any advanced neoplasm (proximal or distal) would be 79, 65 and 66%, respectively. These sensitivities could be increased to up to 86, 83 and 84% by the referral strategies investigated. ...Continue Reading

References

May 11, 1999·JAMA : the Journal of the American Medical Association·T R LevinJ V Selby
Jul 20, 2000·The New England Journal of Medicine·T F ImperialeD F Ransohoff
May 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jun KatoKazuhide Yamamoto
Nov 17, 2009·Gastroenterology·Hermann BrennerMichael Hoffmeister
Jan 1, 2010·Journal of the National Cancer Institute·Hermann BrennerUlrike Haug
May 1, 2010·Lancet·Wendy S AtkinUNKNOWN UK Flexible Sigmoidoscopy Trial Investigators
Mar 8, 2011·Gastrointestinal Endoscopy·Peter B CottonBret Petersen
Aug 20, 2011·Journal of the National Cancer Institute·Nereo SegnanUNKNOWN SCORE Working Group
May 23, 2012·The New England Journal of Medicine·Robert E SchoenUNKNOWN PLCO Project Team
Feb 5, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Han-Mo ChiuMing-Shiang Wu
May 28, 2013·Journal of the National Cancer Institute·Antoni CastellsUNKNOWN COLONPREV study investigators
Jan 15, 2014·Canadian Journal of Gastroenterology & Hepatology·Mary Anne CooperLinda Rabeneck
Aug 15, 2014·JAMA : the Journal of the American Medical Association·Øyvind HolmeGeir Hoff
Feb 24, 2015·Digestive Diseases and Sciences·Robert E Schoen, Jorge D Machicado
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martin C S WongJoseph J Y Sung
Aug 11, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Jasper L A VleugelsEvelien Dekker
Jun 16, 2016·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceAlbert L Siu
Feb 6, 2017·International Journal of Cancer. Journal International Du Cancer·Hermann BrennerHongda Chen
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Jul 22, 2018·Analytical Cellular Pathology (Amsterdam)·Carolina Meloni VicenteLeny Toma
May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Aug 18, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emma C Robbins, Amanda J Cross
Jul 20, 2021·International Journal of Cancer. Journal International Du Cancer·Tobias NiedermaierHermann Brenner

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

KolosSal
R
NORCCAP
R package “ binom ”

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.