Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

Frontiers in Immunology
Carlos Del FresnoDavid Sancho

Abstract

Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation.

References

Jan 1, 1994·Annual Review of Immunology·P Matzinger
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·A B BakkerL L Lanier
Sep 22, 2001·The Journal of Biological Chemistry·J A WillmentG D Brown
Feb 14, 2002·The Journal of Investigative Dermatology·Nobuo KanazawaYoshiki Miyachi
Apr 16, 2002·Science·Polly Matzinger
Jan 8, 2003·The Journal of Experimental Medicine·Teunis B H GeijtenbeekYvette Van Kooyk
Apr 30, 2003·The Journal of Experimental Medicine·Benjamin N GantnerDavid M Underhill
Apr 20, 2005·The Journal of Experimental Medicine·Klaas P J M van GisbergenYvette van Kooyk
Dec 13, 2005·Nature Reviews. Immunology·Gordon D Brown
Nov 18, 2006·Nature Immunology·Matthew J RobinsonCaetano Reis e Sousa
Dec 13, 2006·Nature Immunology·Philip R TaylorGordon D Brown
Jan 2, 2007·Trends in Immunology·David M Underhill, Helen S Goodridge
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen S GoodridgeDavid M Underhill
Mar 7, 2007·The Journal of Biological Chemistry·Gemma L J FullerAndrew C Pearce
Apr 24, 2007·Nature Immunology·Salomé LeibundGut-LandmannCaetano Reis e Sousa
Apr 27, 2007·European Journal of Immunology·Emma C SlackCaetano Reis e Sousa
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonio Gigliotti RothfuchsAlan Sher
Apr 15, 2008·The Journal of Biological Chemistry·Cristal HuysamenGordon D Brown
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A WellsRobert B Ashman
May 24, 2008·The Journal of Clinical Investigation·David SanchoCaetano Reis e Sousa
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcela RosasPhilip R Taylor
Sep 9, 2008·Nature Immunology·Sho YamasakiTakashi Saito
Nov 26, 2008·Journal of Leukocyte Biology·Friederike Meyer-WentrupGosse J Adema
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen S GoodridgeDavid M Underhill
Jan 9, 2009·European Journal of Immunology·Patricia Hernanz-FalcónCaetano Reis e Sousa
Jan 13, 2009·The Journal of Biological Chemistry·Shengli XuKong-Peng Lam
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sho YamasakiTakashi Saito
Jun 13, 2009·Nature Reviews. Immunology·Teunis B H Geijtenbeek, Sonja I Gringhuis

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Citations

May 5, 2020·The Journal of Infectious Diseases·Theodore J KottomAndrew H Limper
Jul 24, 2020·International Journal of Molecular Sciences·Dimitri Leonid Lindenwald, Bernd Lepenies
Feb 26, 2019·The Journal of Experimental Medicine·Peter ReininkIldiko Van Rhijn
Apr 25, 2019·Journal of Hematology & Oncology·Hongbing MaYuping Gong
Mar 7, 2020·Frontiers in Immunology·Marion DrouinElise Chiffoleau
Nov 15, 2019·The Journal of Clinical Investigation·Marie N'diayeMaja Jagodic
Mar 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristopher A KleskiPeter R Andreana
Sep 3, 2020·Cells·Maximiliano L CacicedoMatthias Bros
Jan 11, 2020·Frontiers in Immunology·J Kenneth HooberRobert Cote
Sep 27, 2019·Frontiers in Immunology·Carlos Del FresnoDavid Sancho
Dec 18, 2019·Cellular & Molecular Immunology·Zhida LiuYang-Xin Fu
Nov 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Femke D HollwedelUlrich A Maus
Dec 15, 2020·Clinical & Translational Immunology·Laurissa OuaguiaCaroline Aspord
Feb 10, 2021·Infectious Disease Reports·Andrew R McGillShyam S Mohapatra
Oct 10, 2020·Current Opinion in Immunology·Carlos Del Fresno, David Sancho
Mar 9, 2021·Frontiers in Immunology·Charlotte CastenmillerYvette van Kooyk
Sep 27, 2020·BMC Genomics·Alec Vallota-EastmanBlair G Paul
Dec 27, 2018·International Immunopharmacology·Yuki MasudaMorichika Konishi
May 31, 2021·Trends in Immunology·B C Keumatio DoungstopY van Kooyk

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Methods Mentioned

BETA
glycosylation
nuclear translocation
acetylation

Software Mentioned

SIGN
DC
Mincle

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