FLI1 gene influences lesion size and skin test may predict therapeutic response in cutaneous leishmaniasis

Memórias do Instituto Oswaldo Cruz
Anadilton Santos da HoraLéa Cristina Castellucci

Abstract

Genes associated with wound healing have been shown to be risk factors for cutaneous leishmaniasis (CL) which is caused by Leishmania braziliensis. In this study, we examined whether the genes previously associated with CL influenced the clinical outcome. Patients were genotyped and retrospectively classified as responders, who were cured with a single course of pentavalent antimony (Sbv), or as refractories, who did not respond to Sbv. Patients characterised as responders showed a stronger response to the leishmanin skin test (LST) when compared to the refractory subjects (p = 0.0003). Furthermore, we observed an association between the FLI1 CC genotype and an increased size of ulcers (p = 0.0170). We suggest that the leishmanin skin test may be a predictive tool for therapeutic outcome and reinforce FLI1 as a potential influencer of susceptibility and lesion size in CL.

References

May 30, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Shyam SundarM Rai
Apr 7, 2010·Infection and Immunity·Anuratha SakthianandeswarenEmanuela Handman
Jun 3, 2011·Genes and Immunity·L CastellucciJ M Blackwell
May 5, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Léa CastellucciJenefer M Blackwell
May 28, 2014·Memórias do Instituto Oswaldo Cruz·Léa Cristina CastellucciJenefer Mary Blackwell
Sep 18, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Liliane de Fátima AntonioArmando de Oliveira Schubach
Nov 3, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda V de O PratesPaulo R L Machado

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Citations

Oct 17, 2020·Cytokine·Imtissal Krayem, Marie Lipoldová

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Methods Mentioned

BETA
genotyping

Software Mentioned

GraphPad Prism

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