Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease

Frontiers in Immunology
Zlatko KopeckiAllison Cowin

Abstract

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease characterized by excessive inflammation and disrupted skin barrier function. Although the etiology of AD is not completely understood, clinical and basic studies suggest increasing involvement of autoantibodies against intracellular proteins. An actin remodeling protein, Flightless I (Flii), has been shown to promote development of inflammatory mediated skin conditions and impairment of skin barrier development and function. Here, we sought to determine the effect of altering Flii expression on the development of AD and its contribution to autoimmune aspects of inflammatory skin conditions. Ovalbumin (OVA)-induced AD skin-like disease was induced in Flii heterozygous (Flii+/- ), wild-type (Flii+/+ ), and Flii transgenic (FliiTg/Tg ) mice by epicutaneous exposure to OVA for 3 weeks; each week was separated by 2-week resting period. Reduced Flii expression resulted in decreased disease severity and tissue inflammation as determined by histology, lymphocytic, and mast cell infiltrate and increased anti-inflammatory IL-10 cytokine levels and a marked IFN-γ Th1 response. In contrast, Flii over-expression lead to a Th2 skewed response characterized by increased pr...Continue Reading

References

Oct 3, 1999·International Immunology·K OhkouchiM Shimizu
Oct 19, 1999·The Journal of Clinical Investigation·C VestergaardK Matsushima
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·R L OchsE M Tan
Mar 10, 2001·Journal of Dermatological Science·Y Muro
Apr 25, 2002·Molecular and Cellular Biology·Hugh D CampbellKlaus I Matthaei
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Irene MittermannRudolf Valenta
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tianyi WangXian Chen
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Bernhard HomeyDonald Y M Leung
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G WangH Alenius
May 29, 2007·The International Journal of Biochemistry & Cell Biology·Z Kopecki, A J Cowin
Feb 13, 2009·The Journal of Investigative Dermatology·Zlatko KopeckiAllison J Cowin
Dec 26, 2009·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Naoyuki HigashiSeiji Kawana
Feb 19, 2011·Autoimmunity·Kanako WatanabeYasushi Tomita
May 18, 2011·Current Problems in Dermatology·Kei-ichi Yamanaka, Hitoshi Mizutani
Mar 14, 2012·The Journal of Allergy and Clinical Immunology·Ting Seng TangHywel C Williams
Jan 22, 2013·Communicative & Integrative Biology·Allison J CowinRachael Z Murray
Nov 28, 2013·Postȩpy dermatologii i alergologii·Anna WoźniackaAnna Sysa-Jędrzejowska
May 9, 2014·The Journal of Dermatology·Francesca CiprianiElena Galli
Oct 8, 2014·Expert Opinion on Emerging Drugs·Sabine G PlötzJohannes Ring
Dec 6, 2014·Cellular Signalling·Jin Sil ChoiJang Hyun Choi
Mar 24, 2016·Asian Pacific Journal of Allergy and Immunology·Enza D'AuriaAmilcare Cerri
Nov 1, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Cristián Navarrete-DechentArturo Borzutzky
Sep 1, 2016·Journal of Immunology Research·Isabela SiloşiCristian A Siloşi
Oct 6, 2016·The Journal of Allergy and Clinical Immunology·David A EwaldEmma Guttman-Yassky
Sep 16, 2017·Current Opinion in Immunology·Kenji Kabashima, Takashi Nomura

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Citations

Oct 16, 2019·Journal of Cutaneous Pathology·Zlatko KopeckiAllison Cowin
Aug 29, 2020·Journal of Orthopaedic Surgery and Research·Jessica E JacksonAllison J Cowin
Oct 4, 2020·International Journal of Molecular Sciences·Kevin FenixZlatko Kopecki
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Xanthe L Strudwick, Allison J Cowin

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Methods Mentioned

BETA
transgenic
biopsies
light microscopy
Fluorescence
PCR
fluorescence microscopy

Software Mentioned

GeneSnap
Image Pro - Plus
CellSense Live Science Imaging

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