Flipping a G-tetrad in a unimolecular quadruplex without affecting its global fold

Angewandte Chemie
Jonathan Dickerhoff, Klaus Weisz

Abstract

A unimolecular G-quadruplex with a hybrid-type topology and propeller, diagonal, and lateral loops was examined for its ability to undergo structural changes upon specific modifications. Substituting 2'-deoxy-2'-fluoro analogues with a propensity to adopt an anti glycosidic conformation for two or three guanine deoxyribonucleosides in syn positions of the 5'-terminal G-tetrad significantly alters the CD spectral signature of the quadruplex. An NMR analysis reveals a polarity switch of the whole tetrad with glycosidic conformational changes detected for all four guanine nucleosides in the modified sequence. As no additional rearrangement of the overall fold occurs, a novel type of G-quadruplex is formed with guanosines in the four columnar G-tracts lined up in either an all-syn or an all-anti glycosidic conformation.

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Citations

May 24, 2016·The Journal of Physical Chemistry. B·Di Luo, Yuguang Mu
Mar 21, 2017·ACS Chemical Biology·Jonathan DickerhoffKlaus Weisz
Sep 26, 2016·Journal of Inorganic Biochemistry·Taiga FujiiNaoki Sugimoto
Feb 21, 2018·Chembiochem : a European Journal of Chemical Biology·Jonathan Dickerhoff, Klaus Weisz
May 15, 2018·Chemistry : a European Journal·Beatrice Karg, Klaus Weisz
Nov 14, 2015·Angewandte Chemie·Vee Vee CheongAnh Tuân Phan
Aug 8, 2018·Chemistry : a European Journal·Linn HaaseKlaus Weisz
Sep 18, 2018·Angewandte Chemie·Martina Lenarčič ŽivkovićJanez Plavec
Dec 5, 2018·Chembiochem : a European Journal of Chemical Biology·Linn HaaseKlaus Weisz
Apr 6, 2019·Organic & Biomolecular Chemistry·Jana FilitchevaVyacheslav V Filichev
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maja Marušič, Janez Plavec
May 28, 2019·Angewandte Chemie·Beatrice KargKlaus Weisz
Oct 15, 2019·Chemistry : a European Journal·Linn HaaseKlaus Weisz
Sep 6, 2020·Nucleic Acids Research·Linn Haase, Klaus Weisz
Nov 16, 2017·Chemistry : a European Journal·David M EngelhardGuido H Clever
Mar 2, 2021·Chemical Society Reviews·Luke K McKenzieMarcel Hollenstein
Mar 11, 2021·Chemical Communications : Chem Comm·Poulomi DasAnh Tuân Phan
Dec 14, 2016·Biochemistry·Beatrice KargKlaus Weisz
Jan 25, 2018·The Journal of Organic Chemistry·Céline MoriouPascale Clivio
Oct 5, 2017·The Journal of Physical Chemistry Letters·Jonathan Dickerhoff, Klaus Weisz
Nov 13, 2020·The Journal of Physical Chemistry Letters·Rajesh Kumar Reddy SannapureddiBharathwaj Sathyamoorthy
Jan 19, 2019·Journal of the American Chemical Society·Stasė BielskutėPeter Podbevšek

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