Flocculated amorphous nanoparticles for highly supersaturated solutions.

Pharmaceutical Research
Michal E MatteucciKeith P Johnston

Abstract

To recover polymer-stabilized amorphous nanoparticles from aqueous dispersions efficiently by salt flocculation and to show that the particles redisperse and dissolve rapidly to produce highly supersaturated solutions. Nanoparticle dispersions of itraconazole stabilized by nonionic polymers were formed by antisolvent precipitation and immediately flocculated with sodium sulfate, filtered and dried. The size after redispersion in water, crystallinity, and morphology were compared with those for particles produced by spray drying and rapid freezing. Particle drug loading increased to approximately 90% after salt flocculation and removal of excess polymer with the filtrate. The formation of the flocs at constant particle volume fraction led to low fractal dimensions (open flocs), which facilitated redispersion in water to the original primary particle size of approximately 300 nm. Amorphous particles, which were preserved throughout the flocculation-filtration-drying process, dissolved to supersaturation levels of up to 14 in pH 6.8 media. In contrast, both spray dried and rapidly frozen nanoparticle dispersions crystallized and did not produce submicron particle dispersions upon addition to water, nor high supersaturation values....Continue Reading

References

Aug 1, 1975·CRC Critical Reviews in Biochemistry·F Franks, D Eagland
Oct 1, 1991·Antonie van Leeuwenhoek·S A KooijmanA H Stouthamer
Aug 1, 1985·Chemical & Pharmaceutical Bulletin·A HasegawaI Sugimoto
May 1, 1996·Pharmaceutical Research·C Aitken-NicholJ W McGinity
Apr 1, 1999·Biotechnology and Bioengineering·Y F MaaC C Hsu
Feb 9, 2000·Journal of Colloid and Interface Science·N PanditC Koch
Mar 4, 2000·International Journal of Pharmaceutics·C JacobsR H Müller
Jun 28, 2000·Pharmaceutical Research·B C Hancock, M Parks
Jun 9, 2001·International Journal of Pharmaceutics·S L RaghavanJ Hadgraft
Jan 14, 2003·Pharmaceutical Research·Norbert Rasenack, Bernd W Müller
Jan 16, 2003·International Journal of Pharmaceutics·Geert VerreckMarcus E Brewster
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elaine Merisko-LiversidgeEugene R Cooper
Nov 7, 2003·International Journal of Pharmaceutics·Kazunari YamashitaToshikiro Kimura
Apr 22, 2004·Journal of the American Chemical Society·Vinit S MurthyMichael S Wong
Oct 20, 2004·Drug Development and Industrial Pharmacy·Jiahui HuRobert O Williams
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Usanee KumprakobIsao Adachi
May 25, 2006·Drug Development and Industrial Pharmacy·Yucun ZhuJames W McGinity
Oct 3, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Josh D EngstromKeith P Johnston
Oct 4, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Michal E MatteucciRobert O Williams
Aug 25, 2007·Molecular Pharmaceutics·Michal E MatteucciKeith P Johnston

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Citations

Oct 4, 2011·Drug Development and Industrial Pharmacy·Maria A MillerKeith P Johnston
Feb 27, 2010·Journal of Pharmaceutical Sciences·Jasmine M TamKeith P Johnston
May 14, 2011·Advanced Drug Delivery Reviews·Suzanne M D'Addio, Robert K Prud'homme
Aug 13, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Naila A Mugheirbi, Lidia Tajber
Nov 1, 2016·Biomacromolecules·Nikolas T WeissmuellerRobert K Prud'homme
Nov 7, 2016·Journal of Pharmaceutical Sciences·Rajan Jog, Diane J Burgess
Jun 16, 2019·Journal of Translational Medicine·Jie FengRobert K Prud'homme
Aug 6, 2019·International Journal of Biological Macromolecules·Dalia El BaiharyOmaima A Sammour
Nov 5, 2011·Journal of Colloid and Interface Science·Wean Sin Cheow, Kunn Hadinoto
Feb 24, 2010·Molecular Pharmaceutics·Suzanne M D'AddioRobert K Prud'homme
Feb 25, 2009·Molecular Pharmaceutics·Michal E MatteucciKeith P Johnston
Apr 16, 2009·Molecular Pharmaceutics·Varun KumarRobert K Prud'homme
Mar 24, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Wean Sin Cheow, Kunn Hadinoto
Sep 21, 2017·Molecular Pharmaceutics·Yingyue ZhangRobert K Prud'homme

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