PMID: 7538732Jun 1, 1995Paper

Florid vascular proliferation associated with neural and neuroendocrine neoplasms. A diagnostic clue and potential pitfall

The American Journal of Surgical Pathology
P B Gaudin, J Rosai

Abstract

We report the light microscopic and immunohistochemical features of vascular proliferations associated with 26 extracranial neural and neuroendocrine neoplasms including esthesioneuroblastoma, neuroblastoma/ganglioneuroblastoma, the primitive neural component of immature teratoma, mediastinal teratoma, primitive neuroectodermal tumor, intra-abdominal desmoplastic small cell tumor, Merkel cell carcinoma of the skin, and thyroid medullary carcinoma. These vascular proliferations were similar to those associated with high-grade glial neoplasms and were characterized by tufts of vessels with a glomeruloid configuration or by long cords of vessels. Immunohistochemical evaluation documented the presence of endothelial cells, perithelial cells, and basement membrane components within the foci of proliferating vessels. We propose that these vascular proliferations represent a characteristic feature of the neuroendocrine/neural neoplastic phenotype and that they possibly arise as the result of angiogenic factors produced by the neoplastic cells. The presence of these distinctive vascular lesions in the stroma of a poorly differentiated neoplasm should alert the pathologist to the possibility of the neoplasm being of a neural or neuroend...Continue Reading

Citations

Sep 5, 2002·The Journal of Pathology·Tzafra CohenMurray B Resnick
Oct 15, 2009·Cancer Immunology, Immunotherapy : CII·Lance U'RenSteven Dow
Jan 12, 2010·Pathology Oncology Research : POR·Alexandr Svec, Yvonne Bury
Mar 20, 2003·Journal of the National Cancer Institute·Zofia von MarschallStefan Rosewicz
Mar 1, 1996·The American Journal of Surgical Pathology·J J Kepes
Jan 10, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Patricia M BakerRobert H Young
Jun 18, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Francisco F Nogales, David Aguilar
Mar 25, 2008·The American Journal of Dermatopathology·Marina VazmitelDmitry V Kazakov
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Colin J R StewartJason Tan
Mar 1, 1997·The British Journal of Ophthalmology·A J FossS Lightman
May 30, 2006·Journal of Clinical Pathology·M A den BakkerP C Ewing-Graham
Mar 11, 2008·World Journal of Surgical Oncology·Michail PapamichailMichail Digalakis
Jul 8, 2014·The American Journal of Dermatopathology·Simonetta PianaElvira Moscarella
Jun 25, 2008·International Journal of Surgical Pathology·Giovanni FellegaraJuan Rosai
May 3, 2000·Histopathology·S S Banerjee, M Harris
Aug 5, 2015·Journal of Korean Medical Science·Yoon Jin ChaYoung Mog Shim
Nov 5, 1997·Annals of the New York Academy of Sciences·J J Kepes, F Slowik
Jan 15, 2013·Orvosi hetilap·Katalin Barbara HorváthGábor Reuter
Sep 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N A AbrahamsR E Petras
Oct 16, 2016·Journal of Pathology and Translational Medicine·Yun ChaiKyu-Rae Kim
Apr 28, 2009·Advances in Anatomic Pathology·Melissa P PulitzerKlaus J Busam

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