Flow across the human pylorus soon after ingestion of food, studied with duplex sonography. Effect of glyceryl trinitrate

Scandinavian Journal of Gastroenterology
T HauskenA Berstad

Abstract

By means of duplex sonography, gastric emptying can be related to antral motor activity. The aim of this study was to examine gastric emptying in relation to antral contractions during and immediately after ingestion of a liquid meal in healthy subjects and to study the effect of glyceryl trinitrate (GTN) on this early phase of gastric emptying. Ten healthy, non-smoking men (median age, 36 years; range, 29-41 years) were studied twice on separate days, once without drug administration and once after taking a 0.5-mg sublingual GTN tablet 3 min before ingesting 500 ml of a meat soup (20 kcal; Toro). The subjects were investigated during 3 min of fasting, during 3 min of drinking the soup, and during the first 10 min postprandially. Transpyloric forward flow commenced on average 80 sec and 95 sec after the start of drinking the soup without and with GTN, respectively (P = NS). Non-contractile, pulsatile transpyloric flow (that is, pendulating, transpyloric flow not associated with antral contractions) occurred during episodes of concurrent relaxation of the terminal antrum, the pylorus, and the duodenal bulb. This type of flow occurred mainly just before the start of contractile, pulsatile transpyloric flow (associated with propul...Continue Reading

References

May 1, 1992·Scandinavian Journal of Gastroenterology·T Hausken, A Berstad
Dec 1, 1994·Digestive Diseases and Sciences·H D Allescher, E E Daniel
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Citations

Jan 10, 2009·World Journal of Gastroenterology : WJG·Jens Brøndum FrøkjaerHans Gregersen
Jan 29, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S VingerhagenA Berstad
Mar 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R VozzoI M Chapman
Apr 28, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lawrence A Szarka, Michael Camilleri
Aug 30, 2006·Scandinavian Journal of Gastroenterology·Johan A LundingArnold Berstad
Oct 25, 2006·Scandinavian Journal of Gastroenterology·Werner SchwizerMark Fox
Jul 14, 2006·Digestive Diseases and Sciences·Karen L JonesTrygve Hausken
Feb 5, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Robert J L Fraser, Laura Bryant
Oct 13, 2006·Journal of Magnetic Resonance Imaging : JMRI·Monika A KwiatekWerner Schwizer
May 24, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·S Javad BananiBita Geramizadeh
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lawrence A Szarka, Michael Camilleri
Oct 7, 2006·Current Opinion in Gastroenterology·E M Quigley
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Jan 31, 2002·World Journal of Gastroenterology : WJG·Odd Helge GiljaArnold Berstad
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·M W MundtM Samsom
Jan 17, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael P JonesChristine C Ebert
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Mar 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T HauskenM Samsom
Apr 22, 2005·Scandinavian Journal of Gastroenterology·C L ChenL C Huang
Jul 19, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Céline Savoye-ColletAndré Smout

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