Flow and deformation characteristics of a flexible microfluidic channel with axial gradients in wall elasticity.

Soft Matter
Pratyaksh KaranSuman Chakraborty

Abstract

Axial gradients in wall elasticity may have significant implications in the deformation and flow characteristics of a narrow fluidic conduit, bearing far-reaching consequences in physiology and bio-engineering. Here, we present a theoretical and experimental framework for fluid-structure interactions in microfluidic channels with axial gradients in wall elasticity, in an effort to arrive at a potential conceptual foundation for in vitro study of mirovascular physiology. Towards this, we bring out the static deformation and steady flow characteristics of a circular microchannel made of polydimethylsiloxane (PDMS) bulk, considering imposed gradients in the substrate elasticity. In particular, we study two kinds of elasticity variations - a uniformly soft (or hard) channel with a central strip that is hard (or soft), and, increasing elasticity along the length of the channel. The former kind yields a centrally constricted (or expanded) deformed profile in response to the flow. The latter kind leads to increasingly bulged channel radius from inlet to outlet in response to flow. We also formulate an analytical model capturing the essential physics of the underlying elastohydrodynamic interactions. The theoretical predictions match f...Continue Reading

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Citations

Oct 23, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Ivan C Christov
Dec 1, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·A-Reum KimBoxin Zhao

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