PMID: 9662018Jul 14, 1998Paper

Flow cytometric analysis of cell cycle fractions in oral leukoplakia

International Journal of Oral and Maxillofacial Surgery
T SaitoT Kohgo

Abstract

Flow cytometric analysis of cell cycle fractions and DNA ploidy was performed on 39 biopsy specimens of oral leukoplakia. The aneuploidy rate of these leukoplakias was 9/39 (23.1%) and the mean DNA index of the aneuploid lesions was 1.34. The aneuploidy rate was significantly higher in severely dysplastic lesions (8/17) than in mildly dysplastic (1/15, P<0.02) and nondysplastic (0/7, P<0.05) lesions. No significant differences in the percentages of each cell cycle fraction were seen between the diploid and the aneuploid leukoplakias. However, the S-phase fraction of the severely dysplastic lesions (23.0%) among the diploid leukoplakias was higher than those of the mildly dysplastic (12.4%) and nondysplastic (15.5%) lesions, and the difference between the severely dysplastic and the mildly dysplastic lesions was statistically significant (P<0.001). These results suggest that flow cytometric analysis of cell cycle fractions and DNA ploidy might offer additional information for assessing the malignant potential of oral leukoplakias.

References

Mar 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J J PindborgF S Mehta
Oct 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·I R KramerL H Sobin
Jan 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M A KahnJ M Hermann-Petrin
Oct 1, 1991·International Journal of Oral and Maxillofacial Surgery·T SaitoA Amemiya
Mar 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·H H MincerK P Hopkins
May 24, 1984·Nature·M B MathewsJ I Garrels
Feb 1, 1995·International Journal of Oral and Maxillofacial Surgery·T SaitoA Amemiya

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Citations

Jan 30, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Michael BrennanIsaäc van der Waal
Jun 15, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P A VargasP M Speight
Aug 28, 2010·ANZ Journal of Surgery·Rahul KhannaAjay Kumar Khanna
May 2, 2018·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Nikolaos G NikitakisJohn J Sauk

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