PMID: 8957206Nov 1, 1996Paper

Flow cytometric analysis of platelet activation markers CD62P and CD63 in patients with coronary artery disease

European Journal of Clinical Investigation
T MurakamiH Takahashi

Abstract

We investigated whether platelet activation could be quantitatively detected in patients with coronary artery disease using flow cytometric analysis of the expression of CD62P and CD63, which are activation-specific antigens on the platelet surface. Platelet samples were obtained from 16 healthy control subjects and 65 patients, of whom 25 had angiographically normal coronary arteries and 40 had at least one major coronary artery stenosis (> or = 50% narrowing). In both patient groups, CD62P expression was significantly higher than in the control group, but the difference between the two patient groups was not significant. In contrast, CD63 expression did not differ among the three groups. We also compared expression of these antigens after stratifying the patients according to the number of significant coronary artery stenoses. Patients with three-vessel disease had significantly increased CD62P and CD63 expression compared with the other subgroups. Our findings indicate that platelet activation occurs in patients with severe coronary artery stenosis.

Citations

Feb 28, 2006·Journal of Materials Science. Materials in Medicine·Edson Giuliani Ramos FernandesJulio San Román
Apr 9, 2005·Journal of Thrombosis and Thrombolysis·Shosaku NomuraToshiji Iwasaka
Jun 8, 2001·Thrombosis Research·C C CummingsV L Serebruany
Jul 14, 1999·Thrombosis Research·A McNicol, S J Israels
Feb 13, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shigenori KanazawaShirou Fukuhara
May 15, 2002·Clinical Physiology and Functional Imaging·Marcus E McKenzieVictor L Serebruany
Oct 27, 2009·Clinical Neuropharmacology·Nai-Wen TsaiCheng-Hsien Lu
Sep 6, 2000·Clinical and Experimental Immunology·S NomuraS Fukuhara
Oct 15, 2008·Journal of Materials Science. Materials in Medicine·Edson Giuliani Ramos Fernandes, Alvaro Antonio Alencar De Queiroz
Mar 18, 2004·European Journal of Clinical Investigation·N EiblG Schernthaner
Jun 7, 2005·Diabetes Research and Clinical Practice·Nahoko OgataMiyo Matsumura
Jul 15, 2004·The Journal of Laboratory and Clinical Medicine·Katsuko HaraHakuo Takahashi
Apr 6, 2006·Diabetes Research and Clinical Practice·Nahoko OgataMiyo Matsumura
Jun 22, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S NomuraS Fukuhara
Apr 9, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·H KagawaS Fukuhara
Aug 24, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eman Abdel Rahman Ismail, Omneya Ibrahim Youssef
Oct 4, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Noriko MatsumotoToshiji Iwasaka
Jan 3, 2001·Anesthesiology·C M SamamaP Coriat
Dec 12, 1997·American Journal of Hematology·S NomuraS Fukuhara
Nov 25, 2003·Stroke; a Journal of Cerebral Circulation·Masako Yamazaki, Shinichiro Uchiyama
Dec 5, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Norihito InamiToshiji Iwasaka
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Marcus E McKenzieVictor L Serebruany
Nov 5, 2019·Frontiers in Medicine·Nadji HannachiLaurence Camoin-Jau
Jan 23, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P A HolmeP Aukrust

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