PMID: 9191525Jun 15, 1997Paper

Flow cytometric DNA content analysis of 185 soft tissue neoplasms indicates that S-phase fraction is a prognostic factor for sarcomas. French Federation of Cancer Centers (FNCLCC) Sarcoma Group

Cancer
F CollinJ M Coindra

Abstract

The authors determined the flow cytometric (FCM) DNA characteristics of 53 benign tumors and 132 malignant (71 primary, 61 recurrent) soft tissue sarcomas to investigate their heterogeneity and to evaluate the prognostic values of DNA ploidy status and S-phase fraction (SPF). One to 11 frozen samples were collected from 185 tumors at 10 participating centers of the French Federation of Cancer Centers (FNCLCC). All FCM analyses were performed in the same laboratory. Histologic diagnoses were collegially reviewed, and grade was assessed by the pathologists of the FNCLCC Sarcoma Group. Relationships between FCM, clinical, and pathologic data were investigated using univariate and multivariate analyses for risks of mortality and metastasis. All except 2 of the 53 benign lesions were DNA diploid. One schwannoma and one desmoid tumor exhibited small abnormal DNA peaks. SPF was low in all benign lesions. One-third of the sarcomas were DNA diploid, whereas two-thirds were DNA aneuploid. Relationships were found between aneuploidy and mitotic count, grade, and histologic subtype of malignant fibrous histiocytoma. DNA ploidy status did not influence the clinical outcome. Multiple sampling performed in 32 sarcomas showed both diploid and ...Continue Reading

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Citations

Feb 19, 1999·Journal of Clinical Pathology·P J van DiestJ P Baak
Mar 9, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P D StefanovskiS Frustaci
Feb 26, 1999·Journal of the National Cancer Institute·P RudolphR Parwaresch
Mar 10, 1999·British Journal of Cancer·R L HuuhtanenL C Andersson
Jul 23, 1999·Current Opinion in Oncology·L Y Dirix, A T Van Oosterom
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alessandro OttaianoGaetano Apice

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