Flow cytometric immunophenotyping for hematologic neoplasms

Blood
Fiona E Craig, K A Foon

Abstract

Flow cytometric immunophenotyping remains an indispensable tool for the diagnosis, classification, staging, and monitoring of hematologic neoplasms. The last 10 years have seen advances in flow cytometry instrumentation and availability of an expanded range of antibodies and fluorochromes that have improved our ability to identify different normal cell populations and recognize phenotypic aberrancies, even when present in a small proportion of the cells analyzed. Phenotypically abnormal populations have been documented in many hematologic neoplasms, including lymphoma, chronic lymphoid leukemias, plasma cell neoplasms, acute leukemia, paroxysmal nocturnal hemoglobinuria, mast cell disease, myelodysplastic syndromes, and myeloproliferative disorders. The past decade has also seen refinement of the criteria used to identify distinct disease entities with widespread adoption of the 2001 World Health Organization (WHO) classification. This classification endorses a multiparametric approach to diagnosis and outlines the morphologic, immunophenotypic, and genotypic features characteristic of each disease entity. When should flow cytometric immunophenotyping be applied? The recent Bethesda International Consensus Conference on flow cy...Continue Reading

References

May 1, 1991·Clinical Immunology and Immunopathology·T ShiraiH Nishimura
Jun 1, 1996·American Journal of Clinical Pathology·K NakaseN Kamada
Jul 1, 1996·American Journal of Clinical Pathology·K M AlginoF E Craig
Apr 1, 1997·British Journal of Haematology·A C RawstronG J Morgan
Jun 8, 2000·The American Journal of Surgical Pathology·A DoganP G Isaacson
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K BlakolmerA Chott
Dec 2, 2000·Archives of Pathology & Laboratory Medicine·N K PopnikolovM T Elghetany
Apr 11, 2001·American Journal of Clinical Pathology·D A Arber
May 8, 2001·American Journal of Clinical Pathology·J J TiesingaG Inghirami
Jun 8, 2001·American Journal of Clinical Pathology·C EshoaC C Chang
Jun 8, 2001·American Journal of Clinical Pathology·D JonesY O Huh
Sep 21, 2001·The Journal of Investigative Dermatology·E C VonderheidM Polansky
Oct 17, 2001·American Journal of Clinical Pathology·S JamalS H Kroft
Nov 8, 2001·Leukemia & Lymphoma·C HercherUNKNOWN Groupe Français d'Hématologie Cellulaire
Jan 10, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·T M JelicH H Chang
Feb 28, 2002·American Journal of Clinical Pathology·Yin XuSteven H Kroft
Aug 7, 2002·American Journal of Clinical Pathology·Zach LiuJames Weisberger
Sep 20, 2002·Blood·Marc MaynadiéUNKNOWN Groupe d'Etude Immunologique des Leucémies (GEIL)
Oct 12, 2002·American Journal of Clinical Pathology·Todd S BarryStefania Pittaluga
Nov 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Beverly P NelsonLoAnn C Peterson
Feb 13, 2003·American Journal of Clinical Pathology·Henry Y DongJames Weisberger
May 2, 2003·The New England Journal of Medicine·Marta CrespoEmili Montserrat

❮ Previous
Next ❯

Citations

Jun 12, 2012·Der Pathologe·B Bode, M Tinguely
Nov 27, 2008·International Journal of Hematology·Tohru InabaNaohisa Fujita
Dec 1, 2008·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Renu Saxena, Hema Anand
Mar 1, 2010·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Aruna RanganManorama Bhargava
Sep 3, 2011·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Prashant TembhareAmar Das Gupta
May 4, 2012·Leukemia·J J M van DongenUNKNOWN EuroFlow Consortium (EU-FP6, LSHB-CT-2006-018708)
Sep 6, 2012·Leukemia·T KalinaUNKNOWN EuroFlow Consortium (EU-FP6, LSHB-CT-2006-018708)
May 10, 2011·The American Journal of Dermatopathology·Chris H JokinenHarvey A Greisman
Jun 10, 2008·The Cancer Journal·Paul J Carter, Peter D Senter
Dec 6, 2008·Veterinary Clinical Pathology·Patricia McManus
Oct 2, 2009·Veterinary Clinical Pathology·Mehrdad AmeriTracey Jackson
Mar 23, 2011·Biochemistry. Biokhimii︠a︡·E V Chetverina, A B Chetverin
Aug 30, 2008·Blood·Tucker W LeBien, Thomas F Tedder
Jul 1, 2009·Journal of Translational Medicine·Paolo De Paoli
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roland B WalterJohn M Pagel
Sep 23, 2010·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Howard J Meyerson
Nov 20, 2012·Bioanalysis·Ruth M Barnard
Jul 13, 2013·Blood Reviews·Kathy HeelWendy N Erber
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Anurag GuptaPalanki Satya Dattatreya
Jul 14, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sreejesh SreedharanunniAlka Khadwal
Aug 30, 2013·Molecular Cytogenetics·Walid Al AchkarThomas Liehr
Jun 7, 2011·Journal of Biomedical Optics·Nelly RongeatPhilippe Nérin

❮ Previous
Next ❯