Flow Cytometric Monitoring for Residual Disease in B Lymphoblastic Leukemia Post T Cell Engaging Targeted Therapies

Current Protocols in Cytometry
Sindhu Cherian, Maryalice Stetler-Stevenson

Abstract

The use of targeted therapy is growing in the setting of hematopoietic neoplasms. Flow cytometry is a cornerstone of residual disease monitoring post therapy in this group of malignancies. Often, there is overlap between antigens targeted by immunotherapies and gating reagents utilized for population identification by flow cytometry. Such overlap can render a previously excellent gating reagent inadequate for disease detection. Recently, several anti-CD19 T cell-engaging immunotherapeutic agents and an anti-CD22 immunotoxin have been FDA approved for use in B lymphoblastic leukemia (B-LL), with an anti-CD22 T cell-engaging agent in development. In the setting of such targeted therapies, CD19 and CD22 expression may be altered, compromising the use of these reagents for identification of abnormal blasts. We describe herein a strategy for flow cytometric monitoring for residual disease in patients with B-LL post T cell-engaging anti-CD19 and anti-CD22 therapies. © 2018 by John Wiley & Sons, Inc.

References

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Citations

Nov 26, 2020·American Journal of Clinical Pathology·Sindhu Cherian, Lorinda A Soma
Jan 11, 2021·International Journal of Laboratory Hematology·Rodolfo P CorreiaNydia S Bacal
Mar 26, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nirali N ShahCrystal L Mackall
Feb 20, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hagop M KantarjianAnjali S Advani
Jun 24, 2021·American Journal of Clinical Pathology·Silvia Saumell TutusausWeina Chen

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