Abstract
To asses the expression of myeloid dendritic cells (CD11c+) subset during acute HCV hepatitis and its possible involvement in natural history of the infection. We enrolled 11 patients with acute hepatitis C (AHC) (Group A), 10 patients with acute hepatitis A (AHA) (as infective control-Group B) and 10 healthy donors (group C) in this study. All patients underwent selective flow cytometry gating strategies to assess the peripheral number of the myeloid dendritic cells (mDCs) to understand the possible role and differences during acute hepatitis. Eight of 11 patients with acute HCV hepatitis did not show any increase of mDCs compared to healthy individuals, while a significant decrease of mDCs was found in absolute cell count (z = -2.37; P<0.05) and percentage (z = -2.30; P<0.05) as compared with AHA. On the contrary, The remaining three patients of the group A had a higher mDCs number and percentage as occur in group B. Interestingly, after six months, those patients did not show any increase of mDCs subset were chronically infected. while the three subjects with an increase of peripheral mDCs, as in HAV acute infection, resolved the illness. The lack of increase of mDCs during acute hepatitis C might be an important factor invo...Continue Reading
References
Feb 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L TsaiG C Kuo
May 19, 1997·The Journal of Experimental Medicine·M CellaM Colonna
Dec 31, 1997·The Journal of Clinical Investigation·K M ChangF V Chisari
Feb 19, 1999·Science·M C RissoanY J Liu
May 14, 1999·International Immunology·D D EckelsH Wang
Nov 21, 2001·The Journal of Experimental Medicine·R ThimmeF V Chisari
May 3, 2002·Clinical and Experimental Immunology·S WardP Klenerman
Apr 2, 2003·Journal of Immunological Methods·Xuan Duc NguyenHarald Klüter
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gary L DavisDaniel M Rosenberg
Jun 7, 2003·The Journal of Infectious Diseases·Nadège GoutagnyChristine Bain
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Misako MatsumotoTsukasa Seya
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Feb 21, 2004·Science·Florian HeilStefan Bauer
Mar 3, 2004·The Journal of Clinical Investigation·Noemí SevillaMichael B A Oldstone
Dec 15, 2004·Microbes and Infection·Robert W Finberg, Evelyn A Kurt-Jones
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kui LiStanley M Lemon
Citations
Feb 18, 2011·Journal of Gastroenterology·Angela Dolganiuc, Gyongyi Szabo
Aug 23, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Erwin Daniel Brenndörfer, Matti Sällberg
Nov 28, 2012·Current HIV/AIDS Reports·Rebecca R Terilli, Andrea L Cox
Jul 9, 2014·Journal of Leukocyte Biology·Banishree Saha, Gyongyi Szabo
Nov 30, 2019·Mediators of Inflammation·Grenda Leite PereiraAdriana Malheiro
Apr 23, 2010·International Immunology·Deepa K KrishnadasBabita Agrawal
Sep 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gyongyi SzaboAngela Dolganiuc
Apr 11, 2012·Immunology·Yun ZhouZhansheng Jia
Feb 9, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Deepa RanaSunil K Arora