Flow diverters can occlude aneurysms and preserve arterial branches: a new experimental model.

AJNR. American Journal of Neuroradiology
T E DarsautJ Raymond

Abstract

FDs are new intracranial stents designed to occlude aneurysms while preserving flow to jailed arterial branches. We tested this fundamental principle in a new aneurysm model. Canine lateral wall aneurysms, featuring a branch located immediately opposite the aneurysm, were created in 16 animals to study the effects on aneurysm or branch occlusion using single HP stents (n = 4), 2 overlapping HP stents (n = 4), or an FD (n = 8). Two other animals, in which an efferent arterial branch was anastomosed to the aneurysm fundus, were also treated with FDs. Angiographic results after deployment, at 2 weeks, and at 3 months were scored using an ordinal scale. The metal porosity of the FSS and the amount of FSS neointima formation was determined by postmortem photography. FDs led to better angiographic occlusion scores compared with HP stents (P = .026). FDs were significantly more likely to occlude the aneurysm than the branch (P = .01). When the branch was switched to originate from the aneurysm fundus, the FDs became ineffective (0/2). Neointimal closure of the aneurysm ostium was significantly better with FDs than with single or double HP stents (P = .039). Angiographic occlusion correlated with metallic porosity and neointimal tissue...Continue Reading

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Citations

Jul 12, 2012·Journal of Neurointerventional Surgery·Tim E DarsautJean Raymond
Aug 11, 2012·AJNR. American Journal of Neuroradiology·A MakoyevaJ Raymond
Feb 19, 2016·Medical Image Analysis·Pierre BouillotVitor Mendes Pereira
Apr 15, 2014·International Journal for Numerical Methods in Biomedical Engineering·Juan R CebralDavid Kallmes
Aug 1, 2014·Journal of Neurointerventional Surgery·B FarzinJ Raymond
Nov 26, 2016·AJNR. American Journal of Neuroradiology·R FahedJ Raymond
Jun 13, 2017·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Liang-Der Jou
Mar 8, 2018·The Neuroradiology Journal·Robert FahedJean Raymond
Jun 9, 2017·Journal of Neurointerventional Surgery·Yoshikazu MatsudaDemetrius K Lopes
May 4, 2018·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·G Foa TorresJ M Pumar
Feb 10, 2017·Journal of Neurointerventional Surgery·René AquariusJoost de Vries
Nov 1, 2016·Journal of Neurointerventional Surgery·Miklos MarosfoiMatthew J Gounis
Jan 24, 2019·European Radiology Experimental·Rosa Martínez MorenoHans Henkes
Jul 10, 2017·Journal of Neurointerventional Surgery·Miklos MarosfoiAjit S Puri
Mar 8, 2018·Journal of Neurointerventional Surgery·Jildaz CaroffAjit S Puri
Jun 4, 2020·Journal of Neurointerventional Surgery·Kapilan PanchendraboseAlim P Mitha
Oct 11, 2015·Journal of Neurointerventional Surgery·Jean-Christophe GentricTim Darsaut
Dec 21, 2013·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Alina MakoyevaJean Raymond
Nov 4, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·S B YakovlevI A Aref'eva
May 23, 2013·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·T E DarsautJ Raymond
Mar 1, 2017·Neuroradiology·Robert FahedJean Raymond
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Serge MarbacherJavier Fandino
Jul 8, 2017·Cardiovascular and Interventional Radiology·Maximilian PatzigGunther Fesl
Jun 1, 2018·World Neurosurgery·Ryuta NakaeKensuke Suzuki

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